Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche

Acetylcholine regulates intestinal epithelial secretion via muscarinic Gq-coupled receptors but its role in cell differentiation is unclear. Here, the authors show that Prox1-positive endocrine cells are sensors for the cholinergic intestinal niche and can trigger increased differentiation of entero...

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Autores principales:	Moritz Middelhoff, Henrik Nienhüser, Giovanni Valenti, H. Carlo Maurer, Yoku Hayakawa, Ryota Takahashi, Woosook Kim, Zhengyu Jiang, Ermanno Malagola, Krystle Cuti, Yagnesh Tailor, Leah B. Zamechek, Bernhard W. Renz, Michael Quante, Kelley S. Yan, Timothy C. Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7eeb82d636ca4537aa0b570f2e30840f
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spelling	oai:doaj.org-article:7eeb82d636ca4537aa0b570f2e30840f2021-12-02T14:40:51ZProx1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche10.1038/s41467-019-13850-72041-1723https://doaj.org/article/7eeb82d636ca4537aa0b570f2e30840f2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13850-7https://doaj.org/toc/2041-1723Acetylcholine regulates intestinal epithelial secretion via muscarinic Gq-coupled receptors but its role in cell differentiation is unclear. Here, the authors show that Prox1-positive endocrine cells are sensors for the cholinergic intestinal niche and can trigger increased differentiation of enteroendocrine DCLK1-positive tuft cells.Moritz MiddelhoffHenrik NienhüserGiovanni ValentiH. Carlo MaurerYoku HayakawaRyota TakahashiWoosook KimZhengyu JiangErmanno MalagolaKrystle CutiYagnesh TailorLeah B. ZamechekBernhard W. RenzMichael QuanteKelley S. YanTimothy C. WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Moritz Middelhoff Henrik Nienhüser Giovanni Valenti H. Carlo Maurer Yoku Hayakawa Ryota Takahashi Woosook Kim Zhengyu Jiang Ermanno Malagola Krystle Cuti Yagnesh Tailor Leah B. Zamechek Bernhard W. Renz Michael Quante Kelley S. Yan Timothy C. Wang Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
description	Acetylcholine regulates intestinal epithelial secretion via muscarinic Gq-coupled receptors but its role in cell differentiation is unclear. Here, the authors show that Prox1-positive endocrine cells are sensors for the cholinergic intestinal niche and can trigger increased differentiation of enteroendocrine DCLK1-positive tuft cells.
format	article
author	Moritz Middelhoff Henrik Nienhüser Giovanni Valenti H. Carlo Maurer Yoku Hayakawa Ryota Takahashi Woosook Kim Zhengyu Jiang Ermanno Malagola Krystle Cuti Yagnesh Tailor Leah B. Zamechek Bernhard W. Renz Michael Quante Kelley S. Yan Timothy C. Wang
author_facet	Moritz Middelhoff Henrik Nienhüser Giovanni Valenti H. Carlo Maurer Yoku Hayakawa Ryota Takahashi Woosook Kim Zhengyu Jiang Ermanno Malagola Krystle Cuti Yagnesh Tailor Leah B. Zamechek Bernhard W. Renz Michael Quante Kelley S. Yan Timothy C. Wang
author_sort	Moritz Middelhoff
title	Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
title_short	Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
title_full	Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
title_fullStr	Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
title_full_unstemmed	Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
title_sort	prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7eeb82d636ca4537aa0b570f2e30840f
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Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche

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