Alcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort.

<h4>Background</h4>Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.<h4>Objective</h4>To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later w...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Emmanuelle Kesse-Guyot, Valentina A Andreeva, Claude Jeandel, Monique Ferry, Mathilde Touvier, Serge Hercberg, Pilar Galan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7eeed956498340dfb66850e163e1bbff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7eeed956498340dfb66850e163e1bbff
record_format	dspace
spelling	oai:doaj.org-article:7eeed956498340dfb66850e163e1bbff2021-11-18T08:04:28ZAlcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort.1932-620310.1371/journal.pone.0052311https://doaj.org/article/7eeed956498340dfb66850e163e1bbff2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284983/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.<h4>Objective</h4>To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.<h4>Methods</h4>3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994-1996. Cognitive performance was assessed in 2007-2009 via a battery of 6 neuropsychological tests. A composite score was built as the mean of the standardized individual test scores (mean=50, SD=10). ANCOVA were performed to estimate mean differences in cognitive performance and 95% confidence intervals (CI).<h4>Results</h4>In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference= -1.77; 95% CI: -3.29, -0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference=1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥ 90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.<h4>Conclusion</h4>In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.<h4>Trial registration</h4>ClinicalTrials.gov NCT00272428.Emmanuelle Kesse-GuyotValentina A AndreevaClaude JeandelMonique FerryMathilde TouvierSerge HercbergPilar GalanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52311 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emmanuelle Kesse-Guyot Valentina A Andreeva Claude Jeandel Monique Ferry Mathilde Touvier Serge Hercberg Pilar Galan Alcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort.
description	<h4>Background</h4>Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.<h4>Objective</h4>To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.<h4>Methods</h4>3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994-1996. Cognitive performance was assessed in 2007-2009 via a battery of 6 neuropsychological tests. A composite score was built as the mean of the standardized individual test scores (mean=50, SD=10). ANCOVA were performed to estimate mean differences in cognitive performance and 95% confidence intervals (CI).<h4>Results</h4>In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference= -1.77; 95% CI: -3.29, -0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference=1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥ 90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.<h4>Conclusion</h4>In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.<h4>Trial registration</h4>ClinicalTrials.gov NCT00272428.
format	article
author	Emmanuelle Kesse-Guyot Valentina A Andreeva Claude Jeandel Monique Ferry Mathilde Touvier Serge Hercberg Pilar Galan
author_facet	Emmanuelle Kesse-Guyot Valentina A Andreeva Claude Jeandel Monique Ferry Mathilde Touvier Serge Hercberg Pilar Galan
author_sort	Emmanuelle Kesse-Guyot
title	Alcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort.
title_short	Alcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort.
title_full	Alcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort.
title_fullStr	Alcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort.
title_full_unstemmed	Alcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort.
title_sort	alcohol consumption in midlife and cognitive performance assessed 13 years later in the su.vi.max 2 cohort.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7eeed956498340dfb66850e163e1bbff
work_keys_str_mv	AT emmanuellekesseguyot alcoholconsumptioninmidlifeandcognitiveperformanceassessed13yearslaterinthesuvimax2cohort AT valentinaaandreeva alcoholconsumptioninmidlifeandcognitiveperformanceassessed13yearslaterinthesuvimax2cohort AT claudejeandel alcoholconsumptioninmidlifeandcognitiveperformanceassessed13yearslaterinthesuvimax2cohort AT moniqueferry alcoholconsumptioninmidlifeandcognitiveperformanceassessed13yearslaterinthesuvimax2cohort AT mathildetouvier alcoholconsumptioninmidlifeandcognitiveperformanceassessed13yearslaterinthesuvimax2cohort AT sergehercberg alcoholconsumptioninmidlifeandcognitiveperformanceassessed13yearslaterinthesuvimax2cohort AT pilargalan alcoholconsumptioninmidlifeandcognitiveperformanceassessed13yearslaterinthesuvimax2cohort
_version_	1718422238370201600

Alcohol consumption in midlife and cognitive performance assessed 13 years later in the SU.VI.MAX 2 cohort.

Ejemplares similares