In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy

Abstract Butyrate has a bioactive function to reduce carcinogenesis. To achieve targeted cancer therapy, this study developed bacterial cancer therapy (BCT) with butyrate as a payload. By metabolic engineering, Escherichia coli Nissle 1917 (EcN) was reprogrammed to synthesize butyrate (referred to a...

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Autores principales: Chung-Jen Chiang, Yan-Hong Hong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7ef2b68940fa48df835a93d948504adf
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