Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19). Rapid identification and isolation of infectious patients are critical methods to block COVID-19 transmission. Antigen tests can contribute to prompt identification of infe...

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Autores principales:	Cheng-Chieh Chen, Shou-Cheng Lu, Chyi-Huey Bai, Pei-Yu Wang, Kang-Yun Lee, Yuan-Hung Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antigen test COVID-19 meta-analysis SARS-CoV-2 sensitivity and specificity Medicine R
Acceso en línea:	https://doaj.org/article/7ef70afdc24641c4a47f63153987082f
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spelling	oai:doaj.org-article:7ef70afdc24641c4a47f63153987082f2021-11-11T16:34:34ZDiagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis10.3390/ijerph1821114511660-46011661-7827https://doaj.org/article/7ef70afdc24641c4a47f63153987082f2021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11451https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19). Rapid identification and isolation of infectious patients are critical methods to block COVID-19 transmission. Antigen tests can contribute to prompt identification of infectious individuals. This meta-analysis aims to evaluate the diagnostic accuracy of antigen tests for SARS-CoV-2. We conducted a literature search in PubMed, Embase, the Cochrane Library, and Biomed Central databases. Studies evaluating the diagnostic accuracy of antigen tests for SARS-CoV-2 in community participants were included. Only English-language articles were reviewed. We included eligible studies that provided available data to construct a 2 × 2 table on a per-patient basis. Overall sensitivity and specificity for antigen tests were generated using a bivariate random-effects model. Eighteen studies with 34,865 participants were retrieved. The meta-analysis for SARS-CoV-2 antigen tests generated a pooled sensitivity of 0.82 and a pooled specificity of 1.00. A subgroup analysis of ten studies that reported outcomes for 5629 symptomatic participants generated a pooled sensitivity of 0.87 and a pooled specificity of 1.00. Antigen tests might have higher sensitivity in detecting SARS-CoV-2 in symptomatic patients in the community and may be an effective tool to identify patients to be quarantined to prevent further SARS-CoV-2 transmission.Cheng-Chieh ChenShou-Cheng LuChyi-Huey BaiPei-Yu WangKang-Yun LeeYuan-Hung WangMDPI AGarticleantigen testCOVID-19meta-analysisSARS-CoV-2sensitivity and specificityMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11451, p 11451 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antigen test COVID-19 meta-analysis SARS-CoV-2 sensitivity and specificity Medicine R
spellingShingle	antigen test COVID-19 meta-analysis SARS-CoV-2 sensitivity and specificity Medicine R Cheng-Chieh Chen Shou-Cheng Lu Chyi-Huey Bai Pei-Yu Wang Kang-Yun Lee Yuan-Hung Wang Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis
description	Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19). Rapid identification and isolation of infectious patients are critical methods to block COVID-19 transmission. Antigen tests can contribute to prompt identification of infectious individuals. This meta-analysis aims to evaluate the diagnostic accuracy of antigen tests for SARS-CoV-2. We conducted a literature search in PubMed, Embase, the Cochrane Library, and Biomed Central databases. Studies evaluating the diagnostic accuracy of antigen tests for SARS-CoV-2 in community participants were included. Only English-language articles were reviewed. We included eligible studies that provided available data to construct a 2 × 2 table on a per-patient basis. Overall sensitivity and specificity for antigen tests were generated using a bivariate random-effects model. Eighteen studies with 34,865 participants were retrieved. The meta-analysis for SARS-CoV-2 antigen tests generated a pooled sensitivity of 0.82 and a pooled specificity of 1.00. A subgroup analysis of ten studies that reported outcomes for 5629 symptomatic participants generated a pooled sensitivity of 0.87 and a pooled specificity of 1.00. Antigen tests might have higher sensitivity in detecting SARS-CoV-2 in symptomatic patients in the community and may be an effective tool to identify patients to be quarantined to prevent further SARS-CoV-2 transmission.
format	article
author	Cheng-Chieh Chen Shou-Cheng Lu Chyi-Huey Bai Pei-Yu Wang Kang-Yun Lee Yuan-Hung Wang
author_facet	Cheng-Chieh Chen Shou-Cheng Lu Chyi-Huey Bai Pei-Yu Wang Kang-Yun Lee Yuan-Hung Wang
author_sort	Cheng-Chieh Chen
title	Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis
title_short	Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis
title_full	Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis
title_fullStr	Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis
title_full_unstemmed	Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis
title_sort	diagnostic accuracy of sars-cov-2 antigen tests for community transmission screening: a systematic review and meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7ef70afdc24641c4a47f63153987082f
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Diagnostic Accuracy of SARS-CoV-2 Antigen Tests for Community Transmission Screening: A Systematic Review and Meta-Analysis

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