Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic.

<h4>Objectives</h4>To evaluate therapy for Mycoplasma genitalium infection with doxycycline or azithromycin 1 g compared to five days of azithromycin (total dose 1.5 g).<h4>Methods</h4>A retrospective case study was performed among patients attending the STD-clinic in Falun,...

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Autores principales:	Carin Anagrius, Britta Loré, Jørgen Skov Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ef767f9159c44b3ab0e6725519a849e
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spelling	oai:doaj.org-article:7ef767f9159c44b3ab0e6725519a849e2021-11-18T07:50:08ZTreatment of Mycoplasma genitalium. Observations from a Swedish STD clinic.1932-620310.1371/journal.pone.0061481https://doaj.org/article/7ef767f9159c44b3ab0e6725519a849e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23593483/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>To evaluate therapy for Mycoplasma genitalium infection with doxycycline or azithromycin 1 g compared to five days of azithromycin (total dose 1.5 g).<h4>Methods</h4>A retrospective case study was performed among patients attending the STD-clinic in Falun, Sweden 1998-2005. All patients with a positive PCR test for M. genitalium were routinely offered a test of cure (toc). Response to doxycycline for 9 days, azithromycin 1 g single dose and extended azithromycin (500 mg on day 1 followed by 250 mg o.d. for 4 days) was determined. In patients with treatment failure after azithromycin, macrolide resistance was monitored before and after treatment. Furthermore, the rate of macrolide resistance was monitored for positive specimens available from 2006-2011.<h4>Results</h4>The eradication rate after doxycycline was 43% (48% for women and 38% for men), for azithromycin 1 g 91% (96% for women and 88% for men) and for extended azithromycin 99% (100% for women and 93% for men). Macrolide resistance developed in 7/7 examined (100%) of those testing positive after azithromycin 1 g, but in none of those treated with extended azithromycin. Macrolide resistance before treatment increased from 0% in 2006 and 2007 to 18% in 2011.<h4>Conclusions</h4>These findings confirm the results from other studies showing that doxycycline is inefficient in eradicating M. genitalium. Although azithromycin 1 g was not significantly less efficient than extended dosage, it was associated with selection of macrolide resistant M. genitalium strains and should not be used as first line therapy for M. genitalium. Monitoring of M. genitalium macrolide resistance should be encouraged.Carin AnagriusBritta LoréJørgen Skov JensenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61481 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carin Anagrius Britta Loré Jørgen Skov Jensen Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic.
description	<h4>Objectives</h4>To evaluate therapy for Mycoplasma genitalium infection with doxycycline or azithromycin 1 g compared to five days of azithromycin (total dose 1.5 g).<h4>Methods</h4>A retrospective case study was performed among patients attending the STD-clinic in Falun, Sweden 1998-2005. All patients with a positive PCR test for M. genitalium were routinely offered a test of cure (toc). Response to doxycycline for 9 days, azithromycin 1 g single dose and extended azithromycin (500 mg on day 1 followed by 250 mg o.d. for 4 days) was determined. In patients with treatment failure after azithromycin, macrolide resistance was monitored before and after treatment. Furthermore, the rate of macrolide resistance was monitored for positive specimens available from 2006-2011.<h4>Results</h4>The eradication rate after doxycycline was 43% (48% for women and 38% for men), for azithromycin 1 g 91% (96% for women and 88% for men) and for extended azithromycin 99% (100% for women and 93% for men). Macrolide resistance developed in 7/7 examined (100%) of those testing positive after azithromycin 1 g, but in none of those treated with extended azithromycin. Macrolide resistance before treatment increased from 0% in 2006 and 2007 to 18% in 2011.<h4>Conclusions</h4>These findings confirm the results from other studies showing that doxycycline is inefficient in eradicating M. genitalium. Although azithromycin 1 g was not significantly less efficient than extended dosage, it was associated with selection of macrolide resistant M. genitalium strains and should not be used as first line therapy for M. genitalium. Monitoring of M. genitalium macrolide resistance should be encouraged.
format	article
author	Carin Anagrius Britta Loré Jørgen Skov Jensen
author_facet	Carin Anagrius Britta Loré Jørgen Skov Jensen
author_sort	Carin Anagrius
title	Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic.
title_short	Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic.
title_full	Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic.
title_fullStr	Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic.
title_full_unstemmed	Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic.
title_sort	treatment of mycoplasma genitalium. observations from a swedish std clinic.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7ef767f9159c44b3ab0e6725519a849e
work_keys_str_mv	AT carinanagrius treatmentofmycoplasmagenitaliumobservationsfromaswedishstdclinic AT brittalore treatmentofmycoplasmagenitaliumobservationsfromaswedishstdclinic AT jørgenskovjensen treatmentofmycoplasmagenitaliumobservationsfromaswedishstdclinic
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Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic.

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