Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Cholesterol homeostasis can modulate immunity via multiple pathways. Here the authors show that apolipoprotein E, an important regulator of cholesterol, produced by myeloid cells can regulate T cell activation by controlling the antigen presentation activity of dendritic cells in both humans and mic...

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Autores principales:	Fabrizia Bonacina, David Coe, Guosu Wang, Maria P. Longhi, Andrea Baragetti, Annalisa Moregola, Katia Garlaschelli, Patrizia Uboldi, Fabio Pellegatta, Liliana Grigore, Lorenzo Da Dalt, Andrea Annoni, Silvia Gregori, Qingzhong Xiao, Donatella Caruso, Nico Mitro, Alberico L. Catapano, Federica M. Marelli-Berg, Giuseppe D. Norata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7efaea98bd784e4796780b5a4dbced26
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spelling	oai:doaj.org-article:7efaea98bd784e4796780b5a4dbced262021-12-02T16:56:41ZMyeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation10.1038/s41467-018-05322-12041-1723https://doaj.org/article/7efaea98bd784e4796780b5a4dbced262018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05322-1https://doaj.org/toc/2041-1723Cholesterol homeostasis can modulate immunity via multiple pathways. Here the authors show that apolipoprotein E, an important regulator of cholesterol, produced by myeloid cells can regulate T cell activation by controlling the antigen presentation activity of dendritic cells in both humans and mice.Fabrizia BonacinaDavid CoeGuosu WangMaria P. LonghiAndrea BaragettiAnnalisa MoregolaKatia GarlaschelliPatrizia UboldiFabio PellegattaLiliana GrigoreLorenzo Da DaltAndrea AnnoniSilvia GregoriQingzhong XiaoDonatella CarusoNico MitroAlberico L. CatapanoFederica M. Marelli-BergGiuseppe D. NorataNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabrizia Bonacina David Coe Guosu Wang Maria P. Longhi Andrea Baragetti Annalisa Moregola Katia Garlaschelli Patrizia Uboldi Fabio Pellegatta Liliana Grigore Lorenzo Da Dalt Andrea Annoni Silvia Gregori Qingzhong Xiao Donatella Caruso Nico Mitro Alberico L. Catapano Federica M. Marelli-Berg Giuseppe D. Norata Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
description	Cholesterol homeostasis can modulate immunity via multiple pathways. Here the authors show that apolipoprotein E, an important regulator of cholesterol, produced by myeloid cells can regulate T cell activation by controlling the antigen presentation activity of dendritic cells in both humans and mice.
format	article
author	Fabrizia Bonacina David Coe Guosu Wang Maria P. Longhi Andrea Baragetti Annalisa Moregola Katia Garlaschelli Patrizia Uboldi Fabio Pellegatta Liliana Grigore Lorenzo Da Dalt Andrea Annoni Silvia Gregori Qingzhong Xiao Donatella Caruso Nico Mitro Alberico L. Catapano Federica M. Marelli-Berg Giuseppe D. Norata
author_facet	Fabrizia Bonacina David Coe Guosu Wang Maria P. Longhi Andrea Baragetti Annalisa Moregola Katia Garlaschelli Patrizia Uboldi Fabio Pellegatta Liliana Grigore Lorenzo Da Dalt Andrea Annoni Silvia Gregori Qingzhong Xiao Donatella Caruso Nico Mitro Alberico L. Catapano Federica M. Marelli-Berg Giuseppe D. Norata
author_sort	Fabrizia Bonacina
title	Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
title_short	Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
title_full	Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
title_fullStr	Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
title_full_unstemmed	Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
title_sort	myeloid apolipoprotein e controls dendritic cell antigen presentation and t cell activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7efaea98bd784e4796780b5a4dbced26
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Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

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