Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos

Extensive epigenetic reprogramming occurs during preimplantation embryo development. Here the authors develop a single cell multiomics sequencing technology that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell and apply this me...

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Autores principales:	Yang Wang, Peng Yuan, Zhiqiang Yan, Ming Yang, Ying Huo, Yanli Nie, Xiaohui Zhu, Jie Qiao, Liying Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7efdae7a7382401c91ad28ab2db63e3d
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spelling	oai:doaj.org-article:7efdae7a7382401c91ad28ab2db63e3d2021-12-02T10:59:14ZSingle-cell multiomics sequencing reveals the functional regulatory landscape of early embryos10.1038/s41467-021-21409-82041-1723https://doaj.org/article/7efdae7a7382401c91ad28ab2db63e3d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21409-8https://doaj.org/toc/2041-1723Extensive epigenetic reprogramming occurs during preimplantation embryo development. Here the authors develop a single cell multiomics sequencing technology that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell and apply this method to study mouse preimplantation embryos.Yang WangPeng YuanZhiqiang YanMing YangYing HuoYanli NieXiaohui ZhuJie QiaoLiying YanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Wang Peng Yuan Zhiqiang Yan Ming Yang Ying Huo Yanli Nie Xiaohui Zhu Jie Qiao Liying Yan Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
description	Extensive epigenetic reprogramming occurs during preimplantation embryo development. Here the authors develop a single cell multiomics sequencing technology that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell and apply this method to study mouse preimplantation embryos.
format	article
author	Yang Wang Peng Yuan Zhiqiang Yan Ming Yang Ying Huo Yanli Nie Xiaohui Zhu Jie Qiao Liying Yan
author_facet	Yang Wang Peng Yuan Zhiqiang Yan Ming Yang Ying Huo Yanli Nie Xiaohui Zhu Jie Qiao Liying Yan
author_sort	Yang Wang
title	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_short	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_full	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_fullStr	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_full_unstemmed	Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
title_sort	single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7efdae7a7382401c91ad28ab2db63e3d
work_keys_str_mv	AT yangwang singlecellmultiomicssequencingrevealsthefunctionalregulatorylandscapeofearlyembryos AT pengyuan singlecellmultiomicssequencingrevealsthefunctionalregulatorylandscapeofearlyembryos AT zhiqiangyan singlecellmultiomicssequencingrevealsthefunctionalregulatorylandscapeofearlyembryos AT mingyang singlecellmultiomicssequencingrevealsthefunctionalregulatorylandscapeofearlyembryos AT yinghuo singlecellmultiomicssequencingrevealsthefunctionalregulatorylandscapeofearlyembryos AT yanlinie singlecellmultiomicssequencingrevealsthefunctionalregulatorylandscapeofearlyembryos AT xiaohuizhu singlecellmultiomicssequencingrevealsthefunctionalregulatorylandscapeofearlyembryos AT jieqiao singlecellmultiomicssequencingrevealsthefunctionalregulatorylandscapeofearlyembryos AT liyingyan singlecellmultiomicssequencingrevealsthefunctionalregulatorylandscapeofearlyembryos
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Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos

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