Type 2 diabetes as a risk factor for cognitive impairment: current insights

Hiroyuki Umegaki Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan Abstract: Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction and dementia in the elderly. T2DM has been thought to be associated with vascular d...

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Autor principal:	Umegaki H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	insulin resistance dementia blood glucose amyloid β tau small vascular disease Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7f01f71545cc42108a1ce26eb7ff89c6
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spelling	oai:doaj.org-article:7f01f71545cc42108a1ce26eb7ff89c62021-12-02T06:54:56ZType 2 diabetes as a risk factor for cognitive impairment: current insights1178-1998https://doaj.org/article/7f01f71545cc42108a1ce26eb7ff89c62014-06-01T00:00:00Zhttps://www.dovepress.com/type-2-diabetes-as-a-risk-factor-for-cognitive-impairment-current-insi-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Hiroyuki Umegaki Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan Abstract: Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction and dementia in the elderly. T2DM has been thought to be associated with vascular diseases, eventually leading to vascular dementia, but recent studies have established that T2DM is also associated with Alzheimer’s disease (AD). With the increase in the number of elderly individuals with T2DM, the number of diabetic patients with cognitive dysfunction has been increasing. T2DM may accelerate AD-associated pathologies through insulin resistance. Vascular pathologies may also be associated with cognitive dysfunction and dementia in T2DM subjects. Several other mechanisms also seem to be involved in T2DM-related cognitive dysfunction. More investigations to clarify the association of T2DM with cognitive impairment are warranted. These investigations may help to increase our understanding of AD and open a new door to the development of therapeutics. Recent pharmaceutical advancement in T2DM treatment has resulted in the availability of a wide range of antidiabetics. Some evidence has suggested that antidiabetic therapies help to prevent cognitive dysfunction. At present, however, the optimal level of blood glucose control and the best combination of medications to achieve it in terms of cognitive preservation have not been established. More investigation is warranted. Cognitive dysfunction is an emerging new complication of T2DM that requires further study. Keywords: insulin resistance, dementia, blood glucose, amyloid ß, tau, small vascular diseaseUmegaki HDove Medical Pressarticleinsulin resistancedementiablood glucoseamyloid βtausmall vascular diseaseGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1011-1019 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	insulin resistance dementia blood glucose amyloid β tau small vascular disease Geriatrics RC952-954.6
spellingShingle	insulin resistance dementia blood glucose amyloid β tau small vascular disease Geriatrics RC952-954.6 Umegaki H Type 2 diabetes as a risk factor for cognitive impairment: current insights
description	Hiroyuki Umegaki Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan Abstract: Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction and dementia in the elderly. T2DM has been thought to be associated with vascular diseases, eventually leading to vascular dementia, but recent studies have established that T2DM is also associated with Alzheimer’s disease (AD). With the increase in the number of elderly individuals with T2DM, the number of diabetic patients with cognitive dysfunction has been increasing. T2DM may accelerate AD-associated pathologies through insulin resistance. Vascular pathologies may also be associated with cognitive dysfunction and dementia in T2DM subjects. Several other mechanisms also seem to be involved in T2DM-related cognitive dysfunction. More investigations to clarify the association of T2DM with cognitive impairment are warranted. These investigations may help to increase our understanding of AD and open a new door to the development of therapeutics. Recent pharmaceutical advancement in T2DM treatment has resulted in the availability of a wide range of antidiabetics. Some evidence has suggested that antidiabetic therapies help to prevent cognitive dysfunction. At present, however, the optimal level of blood glucose control and the best combination of medications to achieve it in terms of cognitive preservation have not been established. More investigation is warranted. Cognitive dysfunction is an emerging new complication of T2DM that requires further study. Keywords: insulin resistance, dementia, blood glucose, amyloid ß, tau, small vascular disease
format	article
author	Umegaki H
author_facet	Umegaki H
author_sort	Umegaki H
title	Type 2 diabetes as a risk factor for cognitive impairment: current insights
title_short	Type 2 diabetes as a risk factor for cognitive impairment: current insights
title_full	Type 2 diabetes as a risk factor for cognitive impairment: current insights
title_fullStr	Type 2 diabetes as a risk factor for cognitive impairment: current insights
title_full_unstemmed	Type 2 diabetes as a risk factor for cognitive impairment: current insights
title_sort	type 2 diabetes as a risk factor for cognitive impairment: current insights
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/7f01f71545cc42108a1ce26eb7ff89c6
work_keys_str_mv	AT umegakih type2diabetesasariskfactorforcognitiveimpairmentcurrentinsights
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Type 2 diabetes as a risk factor for cognitive impairment: current insights

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