Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time

Treatment response in patient-derived models may serve as a biomarker for response in the clinic. Here, the authors use paired patient-derived mouse xenografts and patient-derived primary culture models from head and neck squamous cell carcinomas, including metastasis, as models for high-throughput...

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Autores principales:	Shumei Chia, Joo-Leng Low, Xiaoqian Zhang, Xue-Lin Kwang, Fui-Teen Chong, Ankur Sharma, Denis Bertrand, Shen Yon Toh, Hui-Sun Leong, Matan T. Thangavelu, Jacqueline S. G. Hwang, Kok-Hing Lim, Thakshayeni Skanthakumar, Hiang-Khoon Tan, Yan Su, Siang Hui Choo, Hannes Hentze, Iain B. H. Tan, Alexander Lezhava, Patrick Tan, Daniel S. W. Tan, Giridharan Periyasamy, Judice L. Y. Koh, N. Gopalakrishna Iyer, Ramanuj DasGupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f061de7c66f4a4eb132f00dff006462
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spelling	oai:doaj.org-article:7f061de7c66f4a4eb132f00dff0064622021-12-02T14:42:36ZPhenotype-driven precision oncology as a guide for clinical decisions one patient at a time10.1038/s41467-017-00451-52041-1723https://doaj.org/article/7f061de7c66f4a4eb132f00dff0064622017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00451-5https://doaj.org/toc/2041-1723Treatment response in patient-derived models may serve as a biomarker for response in the clinic. Here, the authors use paired patient-derived mouse xenografts and patient-derived primary culture models from head and neck squamous cell carcinomas, including metastasis, as models for high-throughput screening of anti-cancer drugs.Shumei ChiaJoo-Leng LowXiaoqian ZhangXue-Lin KwangFui-Teen ChongAnkur SharmaDenis BertrandShen Yon TohHui-Sun LeongMatan T. ThangaveluJacqueline S. G. HwangKok-Hing LimThakshayeni SkanthakumarHiang-Khoon TanYan SuSiang Hui ChooHannes HentzeIain B. H. TanAlexander LezhavaPatrick TanDaniel S. W. TanGiridharan PeriyasamyJudice L. Y. KohN. Gopalakrishna IyerRamanuj DasGuptaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shumei Chia Joo-Leng Low Xiaoqian Zhang Xue-Lin Kwang Fui-Teen Chong Ankur Sharma Denis Bertrand Shen Yon Toh Hui-Sun Leong Matan T. Thangavelu Jacqueline S. G. Hwang Kok-Hing Lim Thakshayeni Skanthakumar Hiang-Khoon Tan Yan Su Siang Hui Choo Hannes Hentze Iain B. H. Tan Alexander Lezhava Patrick Tan Daniel S. W. Tan Giridharan Periyasamy Judice L. Y. Koh N. Gopalakrishna Iyer Ramanuj DasGupta Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
description	Treatment response in patient-derived models may serve as a biomarker for response in the clinic. Here, the authors use paired patient-derived mouse xenografts and patient-derived primary culture models from head and neck squamous cell carcinomas, including metastasis, as models for high-throughput screening of anti-cancer drugs.
format	article
author	Shumei Chia Joo-Leng Low Xiaoqian Zhang Xue-Lin Kwang Fui-Teen Chong Ankur Sharma Denis Bertrand Shen Yon Toh Hui-Sun Leong Matan T. Thangavelu Jacqueline S. G. Hwang Kok-Hing Lim Thakshayeni Skanthakumar Hiang-Khoon Tan Yan Su Siang Hui Choo Hannes Hentze Iain B. H. Tan Alexander Lezhava Patrick Tan Daniel S. W. Tan Giridharan Periyasamy Judice L. Y. Koh N. Gopalakrishna Iyer Ramanuj DasGupta
author_facet	Shumei Chia Joo-Leng Low Xiaoqian Zhang Xue-Lin Kwang Fui-Teen Chong Ankur Sharma Denis Bertrand Shen Yon Toh Hui-Sun Leong Matan T. Thangavelu Jacqueline S. G. Hwang Kok-Hing Lim Thakshayeni Skanthakumar Hiang-Khoon Tan Yan Su Siang Hui Choo Hannes Hentze Iain B. H. Tan Alexander Lezhava Patrick Tan Daniel S. W. Tan Giridharan Periyasamy Judice L. Y. Koh N. Gopalakrishna Iyer Ramanuj DasGupta
author_sort	Shumei Chia
title	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_short	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_full	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_fullStr	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_full_unstemmed	Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
title_sort	phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7f061de7c66f4a4eb132f00dff006462
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Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time

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