Two distinct immunopathological profiles in autopsy lungs of COVID-19

Two distinct immunopathological profiles in autopsy lungs of COVID-19

The immunopathological features of SARS-CoV-2 infection in the lungs remain unclear. Here, the authors provide a comprehensive characterization of post mortem lung tissues of COVID-19 patients and find two distinct patterns characterized by differential expression of interferon stimulated genes (ISG...

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Autores principales: Ronny Nienhold, Yari Ciani, Viktor H. Koelzer, Alexandar Tzankov, Jasmin D. Haslbauer, Thomas Menter, Nathalie Schwab, Maurice Henkel, Angela Frank, Veronika Zsikla, Niels Willi, Werner Kempf, Thomas Hoyler, Mattia Barbareschi, Holger Moch, Markus Tolnay, Gieri Cathomas, Francesca Demichelis, Tobias Junt, Kirsten D. Mertz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7f0708cc25564852941e5c8e8dff32c6
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spelling oai:doaj.org-article:7f0708cc25564852941e5c8e8dff32c62021-12-02T16:57:09ZTwo distinct immunopathological profiles in autopsy lungs of COVID-1910.1038/s41467-020-18854-22041-1723https://doaj.org/article/7f0708cc25564852941e5c8e8dff32c62020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18854-2https://doaj.org/toc/2041-1723The immunopathological features of SARS-CoV-2 infection in the lungs remain unclear. Here, the authors provide a comprehensive characterization of post mortem lung tissues of COVID-19 patients and find two distinct patterns characterized by differential expression of interferon stimulated genes (ISGs), which correlate to viral loads, cytokines, lung damage and time of hospitalization, suggesting ISG profiles to mark disease progressionRonny NienholdYari CianiViktor H. KoelzerAlexandar TzankovJasmin D. HaslbauerThomas MenterNathalie SchwabMaurice HenkelAngela FrankVeronika ZsiklaNiels WilliWerner KempfThomas HoylerMattia BarbareschiHolger MochMarkus TolnayGieri CathomasFrancesca DemichelisTobias JuntKirsten D. MertzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ronny Nienhold
Yari Ciani
Viktor H. Koelzer
Alexandar Tzankov
Jasmin D. Haslbauer
Thomas Menter
Nathalie Schwab
Maurice Henkel
Angela Frank
Veronika Zsikla
Niels Willi
Werner Kempf
Thomas Hoyler
Mattia Barbareschi
Holger Moch
Markus Tolnay
Gieri Cathomas
Francesca Demichelis
Tobias Junt
Kirsten D. Mertz
Two distinct immunopathological profiles in autopsy lungs of COVID-19
description The immunopathological features of SARS-CoV-2 infection in the lungs remain unclear. Here, the authors provide a comprehensive characterization of post mortem lung tissues of COVID-19 patients and find two distinct patterns characterized by differential expression of interferon stimulated genes (ISGs), which correlate to viral loads, cytokines, lung damage and time of hospitalization, suggesting ISG profiles to mark disease progression
format article
author Ronny Nienhold
Yari Ciani
Viktor H. Koelzer
Alexandar Tzankov
Jasmin D. Haslbauer
Thomas Menter
Nathalie Schwab
Maurice Henkel
Angela Frank
Veronika Zsikla
Niels Willi
Werner Kempf
Thomas Hoyler
Mattia Barbareschi
Holger Moch
Markus Tolnay
Gieri Cathomas
Francesca Demichelis
Tobias Junt
Kirsten D. Mertz
author_facet Ronny Nienhold
Yari Ciani
Viktor H. Koelzer
Alexandar Tzankov
Jasmin D. Haslbauer
Thomas Menter
Nathalie Schwab
Maurice Henkel
Angela Frank
Veronika Zsikla
Niels Willi
Werner Kempf
Thomas Hoyler
Mattia Barbareschi
Holger Moch
Markus Tolnay
Gieri Cathomas
Francesca Demichelis
Tobias Junt
Kirsten D. Mertz
author_sort Ronny Nienhold
title Two distinct immunopathological profiles in autopsy lungs of COVID-19
title_short Two distinct immunopathological profiles in autopsy lungs of COVID-19
title_full Two distinct immunopathological profiles in autopsy lungs of COVID-19
title_fullStr Two distinct immunopathological profiles in autopsy lungs of COVID-19
title_full_unstemmed Two distinct immunopathological profiles in autopsy lungs of COVID-19
title_sort two distinct immunopathological profiles in autopsy lungs of covid-19
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/7f0708cc25564852941e5c8e8dff32c6
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