Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography

Abstract Expanding bile leaks after blunt liver trauma require more aggressive treatment than contained bile leaks. In this retrospective study approved by institution review board, we analyzed if non-invasive contrast-enhanced magnetic resonance cholangiography (CEMRC) using hepatocyte-specific con...

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Autores principales:	Yon-Cheong Wong, Li-Jen Wang, Cheng-Hsien Wu, Huan-Wu Chen, Chen-Ju Fu, Kuo-Ching Yuan, Being-Chuan Lin, Yu-Pao Hsu, Shih-Ching Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Bile Leakage Contrast-enhanced Magnetic Resonance Cholangiography (CEMRC) Area Under Receiver Operating Characteristics Curve (AUROC) Detect Bile Leaks Gadoxetic Acid Disodium Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f09400d77d243eaa3633f8a6976b1b6
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spelling	oai:doaj.org-article:7f09400d77d243eaa3633f8a6976b1b62021-12-02T11:40:47ZDetection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography10.1038/s41598-018-32976-02045-2322https://doaj.org/article/7f09400d77d243eaa3633f8a6976b1b62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32976-0https://doaj.org/toc/2045-2322Abstract Expanding bile leaks after blunt liver trauma require more aggressive treatment than contained bile leaks. In this retrospective study approved by institution review board, we analyzed if non-invasive contrast-enhanced magnetic resonance cholangiography (CEMRC) using hepatocyte-specific contrast agent (gadoxetic acid disodium) could detect and characterize traumatic bile leaks. Between March 2012 and December 2014, written informed consents from 22 included patients (17 men, 5 women) with a median age of 24.5 years (IQR 21.8, 36.0 years) were obtained. Biliary tree visualization and bile leak detection on CEMRC acquired at 10, 20, 30, 90 minutes time points were independently graded by three radiologists on a 5-point Likert scale. Intraclass Correlation (ICC) was computed as estimates of interrater reliability. Accuracy was measured by area under receiver operating characteristic curves (AUROC). Biliary tree visualization was the best on CEMRC at 90 minutes (score 4.30) with excellent inter-rater reliability (ICC = 0.930). Of 22 CEMRC, 15 had bile leak (8 expanding, 7 contained). The largest AUROC of bile leak detection by three radiologists were 0.824, 0.914, 0.929 respectively on CEMRC at 90 minutes with ICC of 0.816. In conclusion, bile leaks of blunt liver trauma can be accurately detected and characterized on CEMRC.Yon-Cheong WongLi-Jen WangCheng-Hsien WuHuan-Wu ChenChen-Ju FuKuo-Ching YuanBeing-Chuan LinYu-Pao HsuShih-Ching KangNature PortfolioarticleBile LeakageContrast-enhanced Magnetic Resonance Cholangiography (CEMRC)Area Under Receiver Operating Characteristics Curve (AUROC)Detect Bile LeaksGadoxetic Acid DisodiumMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bile Leakage Contrast-enhanced Magnetic Resonance Cholangiography (CEMRC) Area Under Receiver Operating Characteristics Curve (AUROC) Detect Bile Leaks Gadoxetic Acid Disodium Medicine R Science Q
spellingShingle	Bile Leakage Contrast-enhanced Magnetic Resonance Cholangiography (CEMRC) Area Under Receiver Operating Characteristics Curve (AUROC) Detect Bile Leaks Gadoxetic Acid Disodium Medicine R Science Q Yon-Cheong Wong Li-Jen Wang Cheng-Hsien Wu Huan-Wu Chen Chen-Ju Fu Kuo-Ching Yuan Being-Chuan Lin Yu-Pao Hsu Shih-Ching Kang Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography
description	Abstract Expanding bile leaks after blunt liver trauma require more aggressive treatment than contained bile leaks. In this retrospective study approved by institution review board, we analyzed if non-invasive contrast-enhanced magnetic resonance cholangiography (CEMRC) using hepatocyte-specific contrast agent (gadoxetic acid disodium) could detect and characterize traumatic bile leaks. Between March 2012 and December 2014, written informed consents from 22 included patients (17 men, 5 women) with a median age of 24.5 years (IQR 21.8, 36.0 years) were obtained. Biliary tree visualization and bile leak detection on CEMRC acquired at 10, 20, 30, 90 minutes time points were independently graded by three radiologists on a 5-point Likert scale. Intraclass Correlation (ICC) was computed as estimates of interrater reliability. Accuracy was measured by area under receiver operating characteristic curves (AUROC). Biliary tree visualization was the best on CEMRC at 90 minutes (score 4.30) with excellent inter-rater reliability (ICC = 0.930). Of 22 CEMRC, 15 had bile leak (8 expanding, 7 contained). The largest AUROC of bile leak detection by three radiologists were 0.824, 0.914, 0.929 respectively on CEMRC at 90 minutes with ICC of 0.816. In conclusion, bile leaks of blunt liver trauma can be accurately detected and characterized on CEMRC.
format	article
author	Yon-Cheong Wong Li-Jen Wang Cheng-Hsien Wu Huan-Wu Chen Chen-Ju Fu Kuo-Ching Yuan Being-Chuan Lin Yu-Pao Hsu Shih-Ching Kang
author_facet	Yon-Cheong Wong Li-Jen Wang Cheng-Hsien Wu Huan-Wu Chen Chen-Ju Fu Kuo-Ching Yuan Being-Chuan Lin Yu-Pao Hsu Shih-Ching Kang
author_sort	Yon-Cheong Wong
title	Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography
title_short	Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography
title_full	Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography
title_fullStr	Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography
title_full_unstemmed	Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography
title_sort	detection and characterization of traumatic bile leaks using gd-eob-dtpa enhanced magnetic resonance cholangiography
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7f09400d77d243eaa3633f8a6976b1b6
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Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography

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