The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet

Abstract Despite the increasing evidence of links between human gut and health, the number of gut microbiomes that have been studied to date at a country level are surprisingly low. Mediterranean countries, including some of the most long-lived and healthy countries in the world, have not been consi...

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Autores principales:	Adriel Latorre-Pérez, Marta Hernández, Jose Ramón Iglesias, Javier Morán, Javier Pascual, Manuel Porcar, Cristina Vilanova, Luis Collado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f0b68c749dd47dba17549a94ab933af
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spelling	oai:doaj.org-article:7f0b68c749dd47dba17549a94ab933af2021-11-14T12:20:13ZThe Spanish gut microbiome reveals links between microorganisms and Mediterranean diet10.1038/s41598-021-01002-12045-2322https://doaj.org/article/7f0b68c749dd47dba17549a94ab933af2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01002-1https://doaj.org/toc/2045-2322Abstract Despite the increasing evidence of links between human gut and health, the number of gut microbiomes that have been studied to date at a country level are surprisingly low. Mediterranean countries, including some of the most long-lived and healthy countries in the world, have not been considered so far in those studies at a large scale. The main objective of this work is to characterize the gut microbiome of a healthy adult population of a Mediterranean, paradigmatically healthy country: Spain. Stool samples from 530 healthy volunteers were collected, total metagenomic DNA extracted, and the microbial profiles determined through 16S rRNA metataxonomic sequencing. Our results confirm the associations between several microbial markers and different variables, including sex, age, BMI and diet choices, and bring new insights into the relationship between microbiome and diet in the Spanish population. Remarkably, some of the associations found, such as the decrease of Faecalibacterium with age or the link of Flavonifractor with less healthy dietary habits, have been barely noticed in other large-scale cohorts. On the other hand, a range of links between microorganisms, diet, and lifestyle coincide with those reported in other populations, thus increasing the robustness of such associations and confirming the importance of these microbial markers across different countries. Overall, this study describes the Spanish “normal” microbiome, providing a solid baseline for future studies investigating the effects of gut microbiome composition and deviations in the adherence to the Mediterranean diet.Adriel Latorre-PérezMarta HernándezJose Ramón IglesiasJavier MoránJavier PascualManuel PorcarCristina VilanovaLuis ColladoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adriel Latorre-Pérez Marta Hernández Jose Ramón Iglesias Javier Morán Javier Pascual Manuel Porcar Cristina Vilanova Luis Collado The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
description	Abstract Despite the increasing evidence of links between human gut and health, the number of gut microbiomes that have been studied to date at a country level are surprisingly low. Mediterranean countries, including some of the most long-lived and healthy countries in the world, have not been considered so far in those studies at a large scale. The main objective of this work is to characterize the gut microbiome of a healthy adult population of a Mediterranean, paradigmatically healthy country: Spain. Stool samples from 530 healthy volunteers were collected, total metagenomic DNA extracted, and the microbial profiles determined through 16S rRNA metataxonomic sequencing. Our results confirm the associations between several microbial markers and different variables, including sex, age, BMI and diet choices, and bring new insights into the relationship between microbiome and diet in the Spanish population. Remarkably, some of the associations found, such as the decrease of Faecalibacterium with age or the link of Flavonifractor with less healthy dietary habits, have been barely noticed in other large-scale cohorts. On the other hand, a range of links between microorganisms, diet, and lifestyle coincide with those reported in other populations, thus increasing the robustness of such associations and confirming the importance of these microbial markers across different countries. Overall, this study describes the Spanish “normal” microbiome, providing a solid baseline for future studies investigating the effects of gut microbiome composition and deviations in the adherence to the Mediterranean diet.
format	article
author	Adriel Latorre-Pérez Marta Hernández Jose Ramón Iglesias Javier Morán Javier Pascual Manuel Porcar Cristina Vilanova Luis Collado
author_facet	Adriel Latorre-Pérez Marta Hernández Jose Ramón Iglesias Javier Morán Javier Pascual Manuel Porcar Cristina Vilanova Luis Collado
author_sort	Adriel Latorre-Pérez
title	The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title_short	The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title_full	The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title_fullStr	The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title_full_unstemmed	The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title_sort	spanish gut microbiome reveals links between microorganisms and mediterranean diet
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7f0b68c749dd47dba17549a94ab933af
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The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet

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