Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes

Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, inducing the formation of vascular lesions in the br...

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Autores principales:	Rodrigo Diéguez-Hurtado, Katsuhiro Kato, Benedetto Daniele Giaimo, Melina Nieminen-Kelhä, Hendrik Arf, Francesca Ferrante, Marek Bartkuhn, Tobias Zimmermann, M. Gabriele Bixel, Hanna M. Eilken, Susanne Adams, Tilman Borggrefe, Peter Vajkoczy, Ralf H. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f0f3111c1374c77bebde1826c430b67
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spelling	oai:doaj.org-article:7f0f3111c1374c77bebde1826c430b672021-12-02T17:01:26ZLoss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes10.1038/s41467-019-10643-w2041-1723https://doaj.org/article/7f0f3111c1374c77bebde1826c430b672019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10643-whttps://doaj.org/toc/2041-1723Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, inducing the formation of vascular lesions in the brain.Rodrigo Diéguez-HurtadoKatsuhiro KatoBenedetto Daniele GiaimoMelina Nieminen-KelhäHendrik ArfFrancesca FerranteMarek BartkuhnTobias ZimmermannM. Gabriele BixelHanna M. EilkenSusanne AdamsTilman BorggrefePeter VajkoczyRalf H. AdamsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rodrigo Diéguez-Hurtado Katsuhiro Kato Benedetto Daniele Giaimo Melina Nieminen-Kelhä Hendrik Arf Francesca Ferrante Marek Bartkuhn Tobias Zimmermann M. Gabriele Bixel Hanna M. Eilken Susanne Adams Tilman Borggrefe Peter Vajkoczy Ralf H. Adams Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
description	Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, inducing the formation of vascular lesions in the brain.
format	article
author	Rodrigo Diéguez-Hurtado Katsuhiro Kato Benedetto Daniele Giaimo Melina Nieminen-Kelhä Hendrik Arf Francesca Ferrante Marek Bartkuhn Tobias Zimmermann M. Gabriele Bixel Hanna M. Eilken Susanne Adams Tilman Borggrefe Peter Vajkoczy Ralf H. Adams
author_facet	Rodrigo Diéguez-Hurtado Katsuhiro Kato Benedetto Daniele Giaimo Melina Nieminen-Kelhä Hendrik Arf Francesca Ferrante Marek Bartkuhn Tobias Zimmermann M. Gabriele Bixel Hanna M. Eilken Susanne Adams Tilman Borggrefe Peter Vajkoczy Ralf H. Adams
author_sort	Rodrigo Diéguez-Hurtado
title	Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
title_short	Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
title_full	Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
title_fullStr	Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
title_full_unstemmed	Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes
title_sort	loss of the transcription factor rbpj induces disease-promoting properties in brain pericytes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7f0f3111c1374c77bebde1826c430b67
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Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes

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