An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis.
Synthesis of acetate from carbon dioxide and molecular hydrogen is considered to be the first carbon assimilation pathway on earth. It combines carbon dioxide fixation into acetyl-CoA with the production of ATP via an energized cell membrane. How the pathway is coupled with the net synthesis of ATP...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7f110c58afdf4f82b03ebfdf17283440 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7f110c58afdf4f82b03ebfdf17283440 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7f110c58afdf4f82b03ebfdf172834402021-11-18T07:23:54ZAn ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis.1932-620310.1371/journal.pone.0033439https://doaj.org/article/7f110c58afdf4f82b03ebfdf172834402012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22479398/?tool=EBIhttps://doaj.org/toc/1932-6203Synthesis of acetate from carbon dioxide and molecular hydrogen is considered to be the first carbon assimilation pathway on earth. It combines carbon dioxide fixation into acetyl-CoA with the production of ATP via an energized cell membrane. How the pathway is coupled with the net synthesis of ATP has been an enigma. The anaerobic, acetogenic bacterium Acetobacterium woodii uses an ancient version of this pathway without cytochromes and quinones. It generates a sodium ion potential across the cell membrane by the sodium-motive ferredoxin:NAD oxidoreductase (Rnf). The genome sequence of A. woodii solves the enigma: it uncovers Rnf as the only ion-motive enzyme coupled to the pathway and unravels a metabolism designed to produce reduced ferredoxin and overcome energetic barriers by virtue of electron-bifurcating, soluble enzymes.Anja PoehleinSilke SchmidtAnne-Kristin KasterMeike GoenrichJohn VollmersAndrea ThürmerJohannes BertschKai SchuchmannBirgit VoigtMichael HeckerRolf DanielRudolf K ThauerGerhard GottschalkVolker MüllerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33439 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Anja Poehlein Silke Schmidt Anne-Kristin Kaster Meike Goenrich John Vollmers Andrea Thürmer Johannes Bertsch Kai Schuchmann Birgit Voigt Michael Hecker Rolf Daniel Rudolf K Thauer Gerhard Gottschalk Volker Müller An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis. |
| description |
Synthesis of acetate from carbon dioxide and molecular hydrogen is considered to be the first carbon assimilation pathway on earth. It combines carbon dioxide fixation into acetyl-CoA with the production of ATP via an energized cell membrane. How the pathway is coupled with the net synthesis of ATP has been an enigma. The anaerobic, acetogenic bacterium Acetobacterium woodii uses an ancient version of this pathway without cytochromes and quinones. It generates a sodium ion potential across the cell membrane by the sodium-motive ferredoxin:NAD oxidoreductase (Rnf). The genome sequence of A. woodii solves the enigma: it uncovers Rnf as the only ion-motive enzyme coupled to the pathway and unravels a metabolism designed to produce reduced ferredoxin and overcome energetic barriers by virtue of electron-bifurcating, soluble enzymes. |
| format |
article |
| author |
Anja Poehlein Silke Schmidt Anne-Kristin Kaster Meike Goenrich John Vollmers Andrea Thürmer Johannes Bertsch Kai Schuchmann Birgit Voigt Michael Hecker Rolf Daniel Rudolf K Thauer Gerhard Gottschalk Volker Müller |
| author_facet |
Anja Poehlein Silke Schmidt Anne-Kristin Kaster Meike Goenrich John Vollmers Andrea Thürmer Johannes Bertsch Kai Schuchmann Birgit Voigt Michael Hecker Rolf Daniel Rudolf K Thauer Gerhard Gottschalk Volker Müller |
| author_sort |
Anja Poehlein |
| title |
An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis. |
| title_short |
An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis. |
| title_full |
An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis. |
| title_fullStr |
An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis. |
| title_full_unstemmed |
An ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for ATP synthesis. |
| title_sort |
ancient pathway combining carbon dioxide fixation with the generation and utilization of a sodium ion gradient for atp synthesis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/7f110c58afdf4f82b03ebfdf17283440 |
| work_keys_str_mv |
AT anjapoehlein anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT silkeschmidt anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT annekristinkaster anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT meikegoenrich anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT johnvollmers anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT andreathurmer anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT johannesbertsch anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT kaischuchmann anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT birgitvoigt anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT michaelhecker anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT rolfdaniel anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT rudolfkthauer anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT gerhardgottschalk anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT volkermuller anancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT anjapoehlein ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT silkeschmidt ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT annekristinkaster ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT meikegoenrich ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT johnvollmers ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT andreathurmer ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT johannesbertsch ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT kaischuchmann ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT birgitvoigt ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT michaelhecker ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT rolfdaniel ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT rudolfkthauer ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT gerhardgottschalk ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis AT volkermuller ancientpathwaycombiningcarbondioxidefixationwiththegenerationandutilizationofasodiumiongradientforatpsynthesis |
| _version_ |
1718423542300672000 |