Combined analysis of miR-200 family and its significance for breast cancer

Abstract While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a lo...

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Autores principales:	Andrea Fontana, Raffaela Barbano, Elisa Dama, Barbara Pasculli, Michelina Rendina, Maria Grazia Morritti, Valentina Melocchi, Marina Castelvetere, Vanna Maria Valori, Sara Ravaioli, Sara Bravaccini, Luigi Ciuffreda, Paolo Graziano, Evaristo Maiello, Massimiliano Copetti, Vito Michele Fazio, Manel Esteller, Fabrizio Bianchi, Paola Parrella
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f115660f6094fd1a43b8c2f4d61692a
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spelling	oai:doaj.org-article:7f115660f6094fd1a43b8c2f4d61692a2021-12-02T14:06:56ZCombined analysis of miR-200 family and its significance for breast cancer10.1038/s41598-021-82286-12045-2322https://doaj.org/article/7f115660f6094fd1a43b8c2f4d61692a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82286-1https://doaj.org/toc/2045-2322Abstract While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a long follow-up (H-CSS cohort) and in TCGA-BRCA cohort. Overall, miR-200 family was found upregulated in breast tumors with respect to normal breast tissues while downregulated in more aggressive breast cancer molecular subtypes (i.e. Luminal B, HER2 and triple negative), consistently with their function as repressors of the epithelial-to-mesenchymal transition (EMT). In particular miR-141-3p was found differentially expressed in breast cancer molecular subtypes in both H-CSS and TCGA-BRCA cohorts, and the combined analysis of all miR-200 family members demonstrated a slight predictive accuracy on H-CSS cancer specific survival at 12 years (survival c-statistic: 0.646; 95%CI 0.538–0.754).Andrea FontanaRaffaela BarbanoElisa DamaBarbara PasculliMichelina RendinaMaria Grazia MorrittiValentina MelocchiMarina CastelvetereVanna Maria ValoriSara RavaioliSara BravacciniLuigi CiuffredaPaolo GrazianoEvaristo MaielloMassimiliano CopettiVito Michele FazioManel EstellerFabrizio BianchiPaola ParrellaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea Fontana Raffaela Barbano Elisa Dama Barbara Pasculli Michelina Rendina Maria Grazia Morritti Valentina Melocchi Marina Castelvetere Vanna Maria Valori Sara Ravaioli Sara Bravaccini Luigi Ciuffreda Paolo Graziano Evaristo Maiello Massimiliano Copetti Vito Michele Fazio Manel Esteller Fabrizio Bianchi Paola Parrella Combined analysis of miR-200 family and its significance for breast cancer
description	Abstract While the molecular functions of miR-200 family have been deeply investigated, a role for these miRNAs as breast cancer biomarkers remains largely unexplored. In the attempt to clarify this, we profiled the miR-200 family members expression in a large cohort of breast cancer cases with a long follow-up (H-CSS cohort) and in TCGA-BRCA cohort. Overall, miR-200 family was found upregulated in breast tumors with respect to normal breast tissues while downregulated in more aggressive breast cancer molecular subtypes (i.e. Luminal B, HER2 and triple negative), consistently with their function as repressors of the epithelial-to-mesenchymal transition (EMT). In particular miR-141-3p was found differentially expressed in breast cancer molecular subtypes in both H-CSS and TCGA-BRCA cohorts, and the combined analysis of all miR-200 family members demonstrated a slight predictive accuracy on H-CSS cancer specific survival at 12 years (survival c-statistic: 0.646; 95%CI 0.538–0.754).
format	article
author	Andrea Fontana Raffaela Barbano Elisa Dama Barbara Pasculli Michelina Rendina Maria Grazia Morritti Valentina Melocchi Marina Castelvetere Vanna Maria Valori Sara Ravaioli Sara Bravaccini Luigi Ciuffreda Paolo Graziano Evaristo Maiello Massimiliano Copetti Vito Michele Fazio Manel Esteller Fabrizio Bianchi Paola Parrella
author_facet	Andrea Fontana Raffaela Barbano Elisa Dama Barbara Pasculli Michelina Rendina Maria Grazia Morritti Valentina Melocchi Marina Castelvetere Vanna Maria Valori Sara Ravaioli Sara Bravaccini Luigi Ciuffreda Paolo Graziano Evaristo Maiello Massimiliano Copetti Vito Michele Fazio Manel Esteller Fabrizio Bianchi Paola Parrella
author_sort	Andrea Fontana
title	Combined analysis of miR-200 family and its significance for breast cancer
title_short	Combined analysis of miR-200 family and its significance for breast cancer
title_full	Combined analysis of miR-200 family and its significance for breast cancer
title_fullStr	Combined analysis of miR-200 family and its significance for breast cancer
title_full_unstemmed	Combined analysis of miR-200 family and its significance for breast cancer
title_sort	combined analysis of mir-200 family and its significance for breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7f115660f6094fd1a43b8c2f4d61692a
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Combined analysis of miR-200 family and its significance for breast cancer

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