No evidence of physiological declines with age in an extremely long-lived fish

Abstract Although the pace of senescence varies considerably, the physiological systems that contribute to different patterns of senescence are not well understood, especially in long-lived vertebrates. Long-lived bony fish (i.e., Class Osteichthyes) are a particularly useful model for studies of se...

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Autores principales:	Derek J. Sauer, Britt J. Heidinger, Jeffrey D. Kittilson, Alec R. Lackmann, Mark E. Clark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f16ea942bc54cb8b45466573ef096c1
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spelling	oai:doaj.org-article:7f16ea942bc54cb8b45466573ef096c12021-12-02T13:40:51ZNo evidence of physiological declines with age in an extremely long-lived fish10.1038/s41598-021-88626-52045-2322https://doaj.org/article/7f16ea942bc54cb8b45466573ef096c12021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88626-5https://doaj.org/toc/2045-2322Abstract Although the pace of senescence varies considerably, the physiological systems that contribute to different patterns of senescence are not well understood, especially in long-lived vertebrates. Long-lived bony fish (i.e., Class Osteichthyes) are a particularly useful model for studies of senescence because they can readily be aged and exhibit some of the longest lifespans among vertebrates. In this study we examined the potential relationship between age and multiple physiological systems including: stress levels, immune function, and telomere length in individuals ranging in age from 2 to 99 years old in bigmouth buffalo (Ictiobus cyprinellus), the oldest known freshwater teleost fish. Contrary to expectation, we did not find any evidence for age-related declines in these physiological systems. Instead, older fish appeared to be less stressed and had greater immunity than younger fish, suggesting age-related improvements rather than declines in these systems. There was no significant effect of age on telomeres, but individuals that may be more stressed had shorter telomeres. Taken together, these findings suggest that bigmouth buffalo exhibit negligible senescence in multiple physiological systems despite living for nearly a century.Derek J. SauerBritt J. HeidingerJeffrey D. KittilsonAlec R. LackmannMark E. ClarkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Derek J. Sauer Britt J. Heidinger Jeffrey D. Kittilson Alec R. Lackmann Mark E. Clark No evidence of physiological declines with age in an extremely long-lived fish
description	Abstract Although the pace of senescence varies considerably, the physiological systems that contribute to different patterns of senescence are not well understood, especially in long-lived vertebrates. Long-lived bony fish (i.e., Class Osteichthyes) are a particularly useful model for studies of senescence because they can readily be aged and exhibit some of the longest lifespans among vertebrates. In this study we examined the potential relationship between age and multiple physiological systems including: stress levels, immune function, and telomere length in individuals ranging in age from 2 to 99 years old in bigmouth buffalo (Ictiobus cyprinellus), the oldest known freshwater teleost fish. Contrary to expectation, we did not find any evidence for age-related declines in these physiological systems. Instead, older fish appeared to be less stressed and had greater immunity than younger fish, suggesting age-related improvements rather than declines in these systems. There was no significant effect of age on telomeres, but individuals that may be more stressed had shorter telomeres. Taken together, these findings suggest that bigmouth buffalo exhibit negligible senescence in multiple physiological systems despite living for nearly a century.
format	article
author	Derek J. Sauer Britt J. Heidinger Jeffrey D. Kittilson Alec R. Lackmann Mark E. Clark
author_facet	Derek J. Sauer Britt J. Heidinger Jeffrey D. Kittilson Alec R. Lackmann Mark E. Clark
author_sort	Derek J. Sauer
title	No evidence of physiological declines with age in an extremely long-lived fish
title_short	No evidence of physiological declines with age in an extremely long-lived fish
title_full	No evidence of physiological declines with age in an extremely long-lived fish
title_fullStr	No evidence of physiological declines with age in an extremely long-lived fish
title_full_unstemmed	No evidence of physiological declines with age in an extremely long-lived fish
title_sort	no evidence of physiological declines with age in an extremely long-lived fish
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7f16ea942bc54cb8b45466573ef096c1
work_keys_str_mv	AT derekjsauer noevidenceofphysiologicaldeclineswithageinanextremelylonglivedfish AT brittjheidinger noevidenceofphysiologicaldeclineswithageinanextremelylonglivedfish AT jeffreydkittilson noevidenceofphysiologicaldeclineswithageinanextremelylonglivedfish AT alecrlackmann noevidenceofphysiologicaldeclineswithageinanextremelylonglivedfish AT markeclark noevidenceofphysiologicaldeclineswithageinanextremelylonglivedfish
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No evidence of physiological declines with age in an extremely long-lived fish

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