Pegasus, a small extracellular peptide enhancing short-range diffusion of Wingless

Short open reading frames (smORFs) of less than 100 codons exist in the thousands in metazoan genomes, mostly with yet unknown functions. Here the authors show how a smORF conserved from flies to vertebrates produces a secreted peptide that enhances the diffusion of the cell signalling protein Wingl...

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Autores principales: Emile G. Magny, Ana Isabel Platero, Sarah A. Bishop, Jose I. Pueyo, Daniel Aguilar-Hidalgo, Juan Pablo Couso
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7f17f13f747943899fbf04ba7e53500e
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Sumario:Short open reading frames (smORFs) of less than 100 codons exist in the thousands in metazoan genomes, mostly with yet unknown functions. Here the authors show how a smORF conserved from flies to vertebrates produces a secreted peptide that enhances the diffusion of the cell signalling protein Wingless.