Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells

Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells

Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflammasome activation, elevated immune cell death and r...

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Autores principales: Pamela P. Lee, Damián Lobato-Márquez, Nayani Pramanik, Andrea Sirianni, Vanessa Daza-Cajigal, Elizabeth Rivers, Alessia Cavazza, Gerben Bouma, Dale Moulding, Kjell Hultenby, Lisa S. Westerberg, Michael Hollinshead, Yu-Lung Lau, Siobhan O. Burns, Serge Mostowy, Mona Bajaj-Elliott, Adrian J. Thrasher
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/7f189439f64c4318ac3cf0baaa3c3614
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Sumario:Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflammasome activation, elevated immune cell death and reduced bacterial clearance.

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