Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells

Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflammasome activation, elevated immune cell death and r...

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Autores principales:	Pamela P. Lee, Damián Lobato-Márquez, Nayani Pramanik, Andrea Sirianni, Vanessa Daza-Cajigal, Elizabeth Rivers, Alessia Cavazza, Gerben Bouma, Dale Moulding, Kjell Hultenby, Lisa S. Westerberg, Michael Hollinshead, Yu-Lung Lau, Siobhan O. Burns, Serge Mostowy, Mona Bajaj-Elliott, Adrian J. Thrasher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f189439f64c4318ac3cf0baaa3c3614
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spelling	oai:doaj.org-article:7f189439f64c4318ac3cf0baaa3c36142021-12-02T14:42:35ZWiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells10.1038/s41467-017-01676-02041-1723https://doaj.org/article/7f189439f64c4318ac3cf0baaa3c36142017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01676-0https://doaj.org/toc/2041-1723Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflammasome activation, elevated immune cell death and reduced bacterial clearance.Pamela P. LeeDamián Lobato-MárquezNayani PramanikAndrea SirianniVanessa Daza-CajigalElizabeth RiversAlessia CavazzaGerben BoumaDale MouldingKjell HultenbyLisa S. WesterbergMichael HollinsheadYu-Lung LauSiobhan O. BurnsSerge MostowyMona Bajaj-ElliottAdrian J. ThrasherNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pamela P. Lee Damián Lobato-Márquez Nayani Pramanik Andrea Sirianni Vanessa Daza-Cajigal Elizabeth Rivers Alessia Cavazza Gerben Bouma Dale Moulding Kjell Hultenby Lisa S. Westerberg Michael Hollinshead Yu-Lung Lau Siobhan O. Burns Serge Mostowy Mona Bajaj-Elliott Adrian J. Thrasher Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
description	Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflammasome activation, elevated immune cell death and reduced bacterial clearance.
format	article
author	Pamela P. Lee Damián Lobato-Márquez Nayani Pramanik Andrea Sirianni Vanessa Daza-Cajigal Elizabeth Rivers Alessia Cavazza Gerben Bouma Dale Moulding Kjell Hultenby Lisa S. Westerberg Michael Hollinshead Yu-Lung Lau Siobhan O. Burns Serge Mostowy Mona Bajaj-Elliott Adrian J. Thrasher
author_facet	Pamela P. Lee Damián Lobato-Márquez Nayani Pramanik Andrea Sirianni Vanessa Daza-Cajigal Elizabeth Rivers Alessia Cavazza Gerben Bouma Dale Moulding Kjell Hultenby Lisa S. Westerberg Michael Hollinshead Yu-Lung Lau Siobhan O. Burns Serge Mostowy Mona Bajaj-Elliott Adrian J. Thrasher
author_sort	Pamela P. Lee
title	Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
title_short	Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
title_full	Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
title_fullStr	Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
title_full_unstemmed	Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
title_sort	wiskott-aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7f189439f64c4318ac3cf0baaa3c3614
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Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells

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