Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine

In 2020, SARS-COV-2 put health systems under unprecedented resource and manpower pressure leading to significant number of deaths. Expectedly, researchers sought to shed light on the pathophysiologic background of this novel disease (COVID-19) as well as to facilitate the design of effective therape...

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Autores principales:	Dimitrios A. Vrachatis, Konstantinos A. Papathanasiou, Sotiria G. Giotaki, Konstantinos Raisakis, Charalampos Kossyvakis, Andreas Kaoukis, Fotis Kolokathis, Gerasimos Deftereos, Konstantinos E. Iliodromitis, Dimitrios Avramides, Harilaos Bogossian, Gerasimos Siasos, George Giannopoulos, Bernhard Reimers, Alexandra Lansky, Jean-Claude Tardif, Spyridon Deftereos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 cytokine release syndrome hypercoagulability colchicine cardioprotection Medicine R
Acceso en línea:	https://doaj.org/article/7f199d476d6340c69eb0fd2256992511
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spelling	oai:doaj.org-article:7f199d476d6340c69eb0fd22569925112021-11-11T17:44:54ZImmunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine10.3390/jcm102151282077-0383https://doaj.org/article/7f199d476d6340c69eb0fd22569925112021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5128https://doaj.org/toc/2077-0383In 2020, SARS-COV-2 put health systems under unprecedented resource and manpower pressure leading to significant number of deaths. Expectedly, researchers sought to shed light on the pathophysiologic background of this novel disease (COVID-19) as well as to facilitate the design of effective therapeutic modalities. Indeed, early enough the pivotal role of inflammatory and thrombotic pathways in SARS-COV-2 infection has been illustrated. The purpose of this article is to briefly present the epidemiologic and clinical features of COVID-19, analyze the pathophysiologic importance of immunologic dysregulation and hypercoagulability in developing disease complications and finally to present an up-to-date systematic review of colchicine’s immunomodulating capacity in view of hindering coronavirus complications.Dimitrios A. VrachatisKonstantinos A. PapathanasiouSotiria G. GiotakiKonstantinos RaisakisCharalampos KossyvakisAndreas KaoukisFotis KolokathisGerasimos DeftereosKonstantinos E. IliodromitisDimitrios AvramidesHarilaos BogossianGerasimos SiasosGeorge GiannopoulosBernhard ReimersAlexandra LanskyJean-Claude TardifSpyridon DeftereosMDPI AGarticleCOVID-19cytokine release syndromehypercoagulabilitycolchicinecardioprotectionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5128, p 5128 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 cytokine release syndrome hypercoagulability colchicine cardioprotection Medicine R
spellingShingle	COVID-19 cytokine release syndrome hypercoagulability colchicine cardioprotection Medicine R Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Sotiria G. Giotaki Konstantinos Raisakis Charalampos Kossyvakis Andreas Kaoukis Fotis Kolokathis Gerasimos Deftereos Konstantinos E. Iliodromitis Dimitrios Avramides Harilaos Bogossian Gerasimos Siasos George Giannopoulos Bernhard Reimers Alexandra Lansky Jean-Claude Tardif Spyridon Deftereos Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine
description	In 2020, SARS-COV-2 put health systems under unprecedented resource and manpower pressure leading to significant number of deaths. Expectedly, researchers sought to shed light on the pathophysiologic background of this novel disease (COVID-19) as well as to facilitate the design of effective therapeutic modalities. Indeed, early enough the pivotal role of inflammatory and thrombotic pathways in SARS-COV-2 infection has been illustrated. The purpose of this article is to briefly present the epidemiologic and clinical features of COVID-19, analyze the pathophysiologic importance of immunologic dysregulation and hypercoagulability in developing disease complications and finally to present an up-to-date systematic review of colchicine’s immunomodulating capacity in view of hindering coronavirus complications.
format	article
author	Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Sotiria G. Giotaki Konstantinos Raisakis Charalampos Kossyvakis Andreas Kaoukis Fotis Kolokathis Gerasimos Deftereos Konstantinos E. Iliodromitis Dimitrios Avramides Harilaos Bogossian Gerasimos Siasos George Giannopoulos Bernhard Reimers Alexandra Lansky Jean-Claude Tardif Spyridon Deftereos
author_facet	Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Sotiria G. Giotaki Konstantinos Raisakis Charalampos Kossyvakis Andreas Kaoukis Fotis Kolokathis Gerasimos Deftereos Konstantinos E. Iliodromitis Dimitrios Avramides Harilaos Bogossian Gerasimos Siasos George Giannopoulos Bernhard Reimers Alexandra Lansky Jean-Claude Tardif Spyridon Deftereos
author_sort	Dimitrios A. Vrachatis
title	Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine
title_short	Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine
title_full	Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine
title_fullStr	Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine
title_full_unstemmed	Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine
title_sort	immunologic dysregulation and hypercoagulability as a pathophysiologic background in covid-19 infection and the immunomodulating role of colchicine
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7f199d476d6340c69eb0fd2256992511
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Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine

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