MECHANISMS OF ANTI-PROLIFERATIVE EFFECT PRODUCED BY MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS

Abstract. We investigated the ability of autologous/allogeneic mesenchymal stem cells (MSC) from early passages, derived from bone marrow of patients with multiple sclerosis, to inhibit mitogen/myelin-induced proliferation of memory T cells. It was shown that MSC immunosuppressive potenti...

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Autores principales:	M. M. Zafranskaya, D. B. Nizhegorodova, M. Yu. Yurkevich, S. S. Bagatka, H. I. Ivanchyk, Yana M. Motuzova, A. S. Fedulov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immune suppression mesenchymal stem cells multiple sclerosis prostaglandin e2 indoleamine 2 3-dioxygenase Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7f19bed10f4d40aa8b8a8c89bdb016b4
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spelling	oai:doaj.org-article:7f19bed10f4d40aa8b8a8c89bdb016b42021-11-18T08:03:41ZMECHANISMS OF ANTI-PROLIFERATIVE EFFECT PRODUCED BY MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS1563-06252313-741X10.15789/1563-0625-2011-2-3-237-246https://doaj.org/article/7f19bed10f4d40aa8b8a8c89bdb016b42014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/455https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We investigated the ability of autologous/allogeneic mesenchymal stem cells (MSC) from early passages, derived from bone marrow of patients with multiple sclerosis, to inhibit mitogen/myelin-induced proliferation of memory T cells. It was shown that MSC immunosuppressive potential of myelin-induced T-cell memory proliferation was significantly higher than an appropriate suppressive effect upon mitogenstimulated cells. These data provide an evidence for a possible pathogenetic role of MSCs in suppression of myelin-specific proliferation of effector lymphoid cells. Immunoregulatory mechanisms of mesenchymal stem cells have been determined. It has been shown that both soluble factors and cell-mediated interactions may be involved in immunosuppressive activity of MSCs. Moreover, soluble mediators of MSC immunoregulatory properties, e.c., prostaglandin E2 and indoleamine 2,3-dioxygenase, were not produced in constitutive manner, but they require a paracrine signal from T-lymphocytes. The data obtained may be used for development of an individual approach, in order to estimate immunomodulatory properties of MSCs and for further application of cell cultures in pathogenetic therapy of multiple sclerosis. (Med. Immunol., 2011, vol. 13, N 2-3, pp 237-246)M. M. ZafranskayaD. B. NizhegorodovaM. Yu. YurkevichS. S. BagatkaH. I. IvanchykYana M. MotuzovaA. S. FedulovSPb RAACIarticleimmune suppressionmesenchymal stem cellsmultiple sclerosisprostaglandin e2indoleamine 23-dioxygenaseImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 237-246 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune suppression mesenchymal stem cells multiple sclerosis prostaglandin e2 indoleamine 2 3-dioxygenase Immunologic diseases. Allergy RC581-607
spellingShingle	immune suppression mesenchymal stem cells multiple sclerosis prostaglandin e2 indoleamine 2 3-dioxygenase Immunologic diseases. Allergy RC581-607 M. M. Zafranskaya D. B. Nizhegorodova M. Yu. Yurkevich S. S. Bagatka H. I. Ivanchyk Yana M. Motuzova A. S. Fedulov MECHANISMS OF ANTI-PROLIFERATIVE EFFECT PRODUCED BY MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS
description	Abstract. We investigated the ability of autologous/allogeneic mesenchymal stem cells (MSC) from early passages, derived from bone marrow of patients with multiple sclerosis, to inhibit mitogen/myelin-induced proliferation of memory T cells. It was shown that MSC immunosuppressive potential of myelin-induced T-cell memory proliferation was significantly higher than an appropriate suppressive effect upon mitogenstimulated cells. These data provide an evidence for a possible pathogenetic role of MSCs in suppression of myelin-specific proliferation of effector lymphoid cells. Immunoregulatory mechanisms of mesenchymal stem cells have been determined. It has been shown that both soluble factors and cell-mediated interactions may be involved in immunosuppressive activity of MSCs. Moreover, soluble mediators of MSC immunoregulatory properties, e.c., prostaglandin E2 and indoleamine 2,3-dioxygenase, were not produced in constitutive manner, but they require a paracrine signal from T-lymphocytes. The data obtained may be used for development of an individual approach, in order to estimate immunomodulatory properties of MSCs and for further application of cell cultures in pathogenetic therapy of multiple sclerosis. (Med. Immunol., 2011, vol. 13, N 2-3, pp 237-246)
format	article
author	M. M. Zafranskaya D. B. Nizhegorodova M. Yu. Yurkevich S. S. Bagatka H. I. Ivanchyk Yana M. Motuzova A. S. Fedulov
author_facet	M. M. Zafranskaya D. B. Nizhegorodova M. Yu. Yurkevich S. S. Bagatka H. I. Ivanchyk Yana M. Motuzova A. S. Fedulov
author_sort	M. M. Zafranskaya
title	MECHANISMS OF ANTI-PROLIFERATIVE EFFECT PRODUCED BY MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS
title_short	MECHANISMS OF ANTI-PROLIFERATIVE EFFECT PRODUCED BY MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS
title_full	MECHANISMS OF ANTI-PROLIFERATIVE EFFECT PRODUCED BY MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS
title_fullStr	MECHANISMS OF ANTI-PROLIFERATIVE EFFECT PRODUCED BY MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS
title_full_unstemmed	MECHANISMS OF ANTI-PROLIFERATIVE EFFECT PRODUCED BY MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS
title_sort	mechanisms of anti-proliferative effect produced by mesenchymal stem cells in patients with multiple sclerosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7f19bed10f4d40aa8b8a8c89bdb016b4
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MECHANISMS OF ANTI-PROLIFERATIVE EFFECT PRODUCED BY MESENCHYMAL STEM CELLS IN PATIENTS WITH MULTIPLE SCLEROSIS

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