Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent

Peter Reimer1, Rolf Vosshenrich21Department of Radiology, Klinikum Karlsruhe, Karlsruhe, Germany; 2Radiologen-Gemeinschaftspraxis, MRT im Friederikenstift, Hannover, GermanyAbstract: The value of cross-sectional liver imaging is evaluated by the accuracy, sensitivity, and specificity of the specific...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peter Reimer, Rolf Vosshenrich
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7f1b66e7a0b5412fa80d46dd948cc841
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7f1b66e7a0b5412fa80d46dd948cc841
record_format	dspace
spelling	oai:doaj.org-article:7f1b66e7a0b5412fa80d46dd948cc8412021-12-02T02:10:16ZDetection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent1177-54751177-5491https://doaj.org/article/7f1b66e7a0b5412fa80d46dd948cc8412010-08-01T00:00:00Zhttp://www.dovepress.com/detection-and-characterization-of-liver-lesions-using-gadoxetic-acid-a-a4958https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Peter Reimer1, Rolf Vosshenrich21Department of Radiology, Klinikum Karlsruhe, Karlsruhe, Germany; 2Radiologen-Gemeinschaftspraxis, MRT im Friederikenstift, Hannover, GermanyAbstract: The value of cross-sectional liver imaging is evaluated by the accuracy, sensitivity, and specificity of the specific imaging technique. Magnetic resonance imaging (MRI) has become a key technique for the characterization and detection of focal and diffuse liver disease. More recently, gadoxetic acid, the hepatocyte-specific MR contrast agent, was clinically approved and introduced in many countries. Gadoxetic acid may be considered a &ldquo;molecular imaging&rdquo; probe because the compound is actively taken into hepatocytes via the ATP-dependent organic anion transport system in the plasma membrane for the hepatic uptake. The transport of gadoxetic acid from the cytoplasm to the bile is mainly determined by the capacity of the transport protein glutathione-S-transferase. Gadoxetic acid enhances hepatocyte-containing lesions and improves detection of lesions devoid of normal hepatocytes, such as metastases. Innovative rapid MR acquisition techniques with near isotropic 3D pulse sequences with fat saturation parallel the technical progress made by multidetector computed tomography combined with an impressive improvement in tumor&ndash;liver contrast when used for gadoxetic acid-enhanced MRI. The purpose of this review is to provide an overview of the development, clinical testing, and applications of this novel MR contrast agent.Keywords: hepatocytes, tumor, gadoxetic acid, liver lesions Peter ReimerRolf VosshenrichDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 199-212 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Peter Reimer Rolf Vosshenrich Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent
description	Peter Reimer1, Rolf Vosshenrich21Department of Radiology, Klinikum Karlsruhe, Karlsruhe, Germany; 2Radiologen-Gemeinschaftspraxis, MRT im Friederikenstift, Hannover, GermanyAbstract: The value of cross-sectional liver imaging is evaluated by the accuracy, sensitivity, and specificity of the specific imaging technique. Magnetic resonance imaging (MRI) has become a key technique for the characterization and detection of focal and diffuse liver disease. More recently, gadoxetic acid, the hepatocyte-specific MR contrast agent, was clinically approved and introduced in many countries. Gadoxetic acid may be considered a &ldquo;molecular imaging&rdquo; probe because the compound is actively taken into hepatocytes via the ATP-dependent organic anion transport system in the plasma membrane for the hepatic uptake. The transport of gadoxetic acid from the cytoplasm to the bile is mainly determined by the capacity of the transport protein glutathione-S-transferase. Gadoxetic acid enhances hepatocyte-containing lesions and improves detection of lesions devoid of normal hepatocytes, such as metastases. Innovative rapid MR acquisition techniques with near isotropic 3D pulse sequences with fat saturation parallel the technical progress made by multidetector computed tomography combined with an impressive improvement in tumor&ndash;liver contrast when used for gadoxetic acid-enhanced MRI. The purpose of this review is to provide an overview of the development, clinical testing, and applications of this novel MR contrast agent.Keywords: hepatocytes, tumor, gadoxetic acid, liver lesions
format	article
author	Peter Reimer Rolf Vosshenrich
author_facet	Peter Reimer Rolf Vosshenrich
author_sort	Peter Reimer
title	Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent
title_short	Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent
title_full	Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent
title_fullStr	Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent
title_full_unstemmed	Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent
title_sort	detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/7f1b66e7a0b5412fa80d46dd948cc841
work_keys_str_mv	AT peterreimer detectionandcharacterizationofliverlesionsusinggadoxeticacidasatissuespecificcontrastagent AT rolfvosshenrich detectionandcharacterizationofliverlesionsusinggadoxeticacidasatissuespecificcontrastagent
_version_	1718402657736982528

Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent

Ejemplares similares