Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome

Yaru Wang,1 Junbao Du,1,2 Xueying Li,3 Ping Liu,1 Yuli Wang,1 Ying Liao,1 Hongfang Jin1 1Department of Pediatrics, Peking University First Hospital, Beijing, 100034, People’s Republic of China; 2Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100034, People’s Rep...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang Y, Du J, Li X, Liu P, Liao Y, Jin H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	postural tachycardia syndrome comorbidity allergic disorders prognosis children Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7f1ec5f6d66242fa9ebf6cac5ccf98a5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7f1ec5f6d66242fa9ebf6cac5ccf98a5
record_format	dspace
spelling	oai:doaj.org-article:7f1ec5f6d66242fa9ebf6cac5ccf98a52021-11-28T19:13:10ZImpact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome1178-7074https://doaj.org/article/7f1ec5f6d66242fa9ebf6cac5ccf98a52021-11-01T00:00:00Zhttps://www.dovepress.com/impact-of-comorbidities-on-the-prognosis-of-pediatric-postural-tachyca-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Yaru Wang,1 Junbao Du,1,2 Xueying Li,3 Ping Liu,1 Yuli Wang,1 Ying Liao,1 Hongfang Jin1 1Department of Pediatrics, Peking University First Hospital, Beijing, 100034, People’s Republic of China; 2Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100034, People’s Republic of China; 3Department of Medical Statistics, Peking University First Hospital, Beijing, 100034, People’s Republic of ChinaCorrespondence: Ying Liao; Hongfang JinDepartment of Pediatrics, Peking University First Hospital, Beijing, 100034, People’s Republic of ChinaTel +8610-83573238Fax +8610-66530532Email liaoyingwww@163.com; jinhongfang51@126.comObjective: To investigate the influence of comorbidities on the prognosis of pediatric postural tachycardia syndrome (POTS).Methods: In this retrospective cohort study, 275 children with POTS admitted to the Department of Pediatrics at Peking University First Hospital were recruited from 2016 to 2019 and followed up. The participants were divided into simple POTS (S-POTS, n=156 cases) and POTS with comorbidities (Co-POTS, n=119 cases) groups according to whether they were complicated with comorbidities. A Cox regression analysis was used to identify the prognostic risk factors for children with POTS, while Kaplan–Meier curves were applied to compare the cumulative symptom remission rate (CSRR) between the two groups. The rehospitalization of the children between the two groups was also compared to explore the influence of comorbidities.Results: Twenty-one participants (7.6%) were lost during a median follow-up of 24 months. The Cox regression model showed that comorbidities and body mass index (BMI) were associated with the CSRR of the children with POTS. The CSRR of pediatric POTS alone was 1.748 times higher than that of patients with comorbidities, and the CSRR was decreased by 5.1% for each 1 kg/m2 increase in BMI. The most common comorbidity in children with POTS in this study was allergic disorders, followed by the psychological diseases. The patients in the Co-POTS group had a lower CSRR than those in the S-POTS group (log rank P=0.0001). In addition, compared with those of the S-POTS group, the total number of rehospitalizations was high (P=0.001), and the total hospital stays were long in the Co-POTS group (P< 0.001).Conclusion: Complicating with comorbidities, pediatric patients with POTS had lower CSRR and more rehospitalizations than those without comorbidities. More attention should be given to comorbidities when managing pediatric POTS.Keywords: postural tachycardia syndrome, comorbidity, allergic disorders, prognosis, childrenWang YDu JLi XLiu PWang YLiao YJin HDove Medical Pressarticlepostural tachycardia syndromecomorbidityallergic disordersprognosischildrenMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8945-8954 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	postural tachycardia syndrome comorbidity allergic disorders prognosis children Medicine (General) R5-920
spellingShingle	postural tachycardia syndrome comorbidity allergic disorders prognosis children Medicine (General) R5-920 Wang Y Du J Li X Liu P Wang Y Liao Y Jin H Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome
description	Yaru Wang,1 Junbao Du,1,2 Xueying Li,3 Ping Liu,1 Yuli Wang,1 Ying Liao,1 Hongfang Jin1 1Department of Pediatrics, Peking University First Hospital, Beijing, 100034, People’s Republic of China; 2Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100034, People’s Republic of China; 3Department of Medical Statistics, Peking University First Hospital, Beijing, 100034, People’s Republic of ChinaCorrespondence: Ying Liao; Hongfang JinDepartment of Pediatrics, Peking University First Hospital, Beijing, 100034, People’s Republic of ChinaTel +8610-83573238Fax +8610-66530532Email liaoyingwww@163.com; jinhongfang51@126.comObjective: To investigate the influence of comorbidities on the prognosis of pediatric postural tachycardia syndrome (POTS).Methods: In this retrospective cohort study, 275 children with POTS admitted to the Department of Pediatrics at Peking University First Hospital were recruited from 2016 to 2019 and followed up. The participants were divided into simple POTS (S-POTS, n=156 cases) and POTS with comorbidities (Co-POTS, n=119 cases) groups according to whether they were complicated with comorbidities. A Cox regression analysis was used to identify the prognostic risk factors for children with POTS, while Kaplan–Meier curves were applied to compare the cumulative symptom remission rate (CSRR) between the two groups. The rehospitalization of the children between the two groups was also compared to explore the influence of comorbidities.Results: Twenty-one participants (7.6%) were lost during a median follow-up of 24 months. The Cox regression model showed that comorbidities and body mass index (BMI) were associated with the CSRR of the children with POTS. The CSRR of pediatric POTS alone was 1.748 times higher than that of patients with comorbidities, and the CSRR was decreased by 5.1% for each 1 kg/m2 increase in BMI. The most common comorbidity in children with POTS in this study was allergic disorders, followed by the psychological diseases. The patients in the Co-POTS group had a lower CSRR than those in the S-POTS group (log rank P=0.0001). In addition, compared with those of the S-POTS group, the total number of rehospitalizations was high (P=0.001), and the total hospital stays were long in the Co-POTS group (P< 0.001).Conclusion: Complicating with comorbidities, pediatric patients with POTS had lower CSRR and more rehospitalizations than those without comorbidities. More attention should be given to comorbidities when managing pediatric POTS.Keywords: postural tachycardia syndrome, comorbidity, allergic disorders, prognosis, children
format	article
author	Wang Y Du J Li X Liu P Wang Y Liao Y Jin H
author_facet	Wang Y Du J Li X Liu P Wang Y Liao Y Jin H
author_sort	Wang Y
title	Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome
title_short	Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome
title_full	Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome
title_fullStr	Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome
title_full_unstemmed	Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome
title_sort	impact of comorbidities on the prognosis of pediatric postural tachycardia syndrome
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7f1ec5f6d66242fa9ebf6cac5ccf98a5
work_keys_str_mv	AT wangy impactofcomorbiditiesontheprognosisofpediatricposturaltachycardiasyndrome AT duj impactofcomorbiditiesontheprognosisofpediatricposturaltachycardiasyndrome AT lix impactofcomorbiditiesontheprognosisofpediatricposturaltachycardiasyndrome AT liup impactofcomorbiditiesontheprognosisofpediatricposturaltachycardiasyndrome AT wangy impactofcomorbiditiesontheprognosisofpediatricposturaltachycardiasyndrome AT liaoy impactofcomorbiditiesontheprognosisofpediatricposturaltachycardiasyndrome AT jinh impactofcomorbiditiesontheprognosisofpediatricposturaltachycardiasyndrome
_version_	1718407779599777792

Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome

Ejemplares similares