The role of epigenetic mechanisms and processes in autoimmune disorders

Judith M Greer, Pamela A McCombeThe University of Queensland, UQ Centre for Clinical Research, Brisbane, Queensland, AustraliaAbstract: The lack of complete concordance of autoimmune disease in identical twins suggests that nongenetic factors play a major role in determining disease susceptibility....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Greer JM, McCombe PA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7f26b510753f49c88cea6662f8f4881e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7f26b510753f49c88cea6662f8f4881e
record_format	dspace
spelling	oai:doaj.org-article:7f26b510753f49c88cea6662f8f4881e2021-12-02T02:11:18ZThe role of epigenetic mechanisms and processes in autoimmune disorders1177-54751177-5491https://doaj.org/article/7f26b510753f49c88cea6662f8f4881e2012-09-01T00:00:00Zhttp://www.dovepress.com/the-role-of-epigenetic-mechanisms-and-processes-in-autoimmune-disorder-a10928https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Judith M Greer, Pamela A McCombeThe University of Queensland, UQ Centre for Clinical Research, Brisbane, Queensland, AustraliaAbstract: The lack of complete concordance of autoimmune disease in identical twins suggests that nongenetic factors play a major role in determining disease susceptibility. In this review, we consider how epigenetic mechanisms could affect the immune system and effector mechanisms in autoimmunity and/or the target organ of autoimmunity and thus affect the development of autoimmune diseases. We also consider the types of stimuli that lead to epigenetic modifications and how these relate to the epidemiology of autoimmune diseases and the biological pathways operative in different autoimmune diseases. Increasing our knowledge of these epigenetic mechanisms and processes will increase the prospects for controlling or preventing autoimmune diseases in the future through the use of drugs that target the epigenetic pathways.Keywords: twins, concordance, autoimmune disease, nongenetic factors, immune system, epigenetic modificationsGreer JMMcCombe PADove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2012, Iss default, Pp 307-327 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Greer JM McCombe PA The role of epigenetic mechanisms and processes in autoimmune disorders
description	Judith M Greer, Pamela A McCombeThe University of Queensland, UQ Centre for Clinical Research, Brisbane, Queensland, AustraliaAbstract: The lack of complete concordance of autoimmune disease in identical twins suggests that nongenetic factors play a major role in determining disease susceptibility. In this review, we consider how epigenetic mechanisms could affect the immune system and effector mechanisms in autoimmunity and/or the target organ of autoimmunity and thus affect the development of autoimmune diseases. We also consider the types of stimuli that lead to epigenetic modifications and how these relate to the epidemiology of autoimmune diseases and the biological pathways operative in different autoimmune diseases. Increasing our knowledge of these epigenetic mechanisms and processes will increase the prospects for controlling or preventing autoimmune diseases in the future through the use of drugs that target the epigenetic pathways.Keywords: twins, concordance, autoimmune disease, nongenetic factors, immune system, epigenetic modifications
format	article
author	Greer JM McCombe PA
author_facet	Greer JM McCombe PA
author_sort	Greer JM
title	The role of epigenetic mechanisms and processes in autoimmune disorders
title_short	The role of epigenetic mechanisms and processes in autoimmune disorders
title_full	The role of epigenetic mechanisms and processes in autoimmune disorders
title_fullStr	The role of epigenetic mechanisms and processes in autoimmune disorders
title_full_unstemmed	The role of epigenetic mechanisms and processes in autoimmune disorders
title_sort	role of epigenetic mechanisms and processes in autoimmune disorders
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/7f26b510753f49c88cea6662f8f4881e
work_keys_str_mv	AT greerjm theroleofepigeneticmechanismsandprocessesinautoimmunedisorders AT mccombepa theroleofepigeneticmechanismsandprocessesinautoimmunedisorders AT greerjm roleofepigeneticmechanismsandprocessesinautoimmunedisorders AT mccombepa roleofepigeneticmechanismsandprocessesinautoimmunedisorders
_version_	1718402657920483328

The role of epigenetic mechanisms and processes in autoimmune disorders

Ejemplares similares