Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study
Abstract A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for test...
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Nature Portfolio
2021
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oai:doaj.org-article:7f27f08771074336aabcecb066a0e25c2021-12-02T16:26:38ZClinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study10.1038/s41598-021-93828-y2045-2322https://doaj.org/article/7f27f08771074336aabcecb066a0e25c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93828-yhttps://doaj.org/toc/2045-2322Abstract A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological testing was performed one month after inclusion. Among the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; 65/67 (97.0%) developed mild form of COVID-19. Other respiratory pathogens were found in 6/66 (9.1%) SARS-CoV-2 positive and 47/241 (19.5%) SARS-Cov-2 negative HCWs (p = 0.07). The proportion of HCWs with a viral load > 5.0 log10 cp/mL (Ct value < 25) was less than 15% at 8 days after symptom onset; 12% of HCWs were positive after 40 days (Ct > 37). More than 90% of cultivable virus had a viral load > 4.5 log10 cp/mL (Ct < 26) and were collected within 10 days after symptom onset. Among negative HCWs, 6/190 (3.2%) seroconverted. Our data suggest that the determination of viral load can be used for appreciating the infectiousness of infected HCWs. These data could be helpful for facilitating their return to work.Antonin BalKaren Brengel-PesceAlexandre GaymardGrégory QuéromèsNicolas GuibertEmile FrobertMaude BouscambertMary-Anne TrabaudFlorence Allantaz-FragerGuy OriolValérie CheynetConstance d’AubaredeAmélie Massardier-PiloncheryMarlyse BuissonJulien LupoBruno PozzettoPascal PoignardBruno LinaJean-Baptiste FassierFlorence MorfinSophie Trouillet-AssantCOVID-SER Study groupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Antonin Bal Karen Brengel-Pesce Alexandre Gaymard Grégory Quéromès Nicolas Guibert Emile Frobert Maude Bouscambert Mary-Anne Trabaud Florence Allantaz-Frager Guy Oriol Valérie Cheynet Constance d’Aubarede Amélie Massardier-Pilonchery Marlyse Buisson Julien Lupo Bruno Pozzetto Pascal Poignard Bruno Lina Jean-Baptiste Fassier Florence Morfin Sophie Trouillet-Assant COVID-SER Study group Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study |
| description |
Abstract A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological testing was performed one month after inclusion. Among the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; 65/67 (97.0%) developed mild form of COVID-19. Other respiratory pathogens were found in 6/66 (9.1%) SARS-CoV-2 positive and 47/241 (19.5%) SARS-Cov-2 negative HCWs (p = 0.07). The proportion of HCWs with a viral load > 5.0 log10 cp/mL (Ct value < 25) was less than 15% at 8 days after symptom onset; 12% of HCWs were positive after 40 days (Ct > 37). More than 90% of cultivable virus had a viral load > 4.5 log10 cp/mL (Ct < 26) and were collected within 10 days after symptom onset. Among negative HCWs, 6/190 (3.2%) seroconverted. Our data suggest that the determination of viral load can be used for appreciating the infectiousness of infected HCWs. These data could be helpful for facilitating their return to work. |
| format |
article |
| author |
Antonin Bal Karen Brengel-Pesce Alexandre Gaymard Grégory Quéromès Nicolas Guibert Emile Frobert Maude Bouscambert Mary-Anne Trabaud Florence Allantaz-Frager Guy Oriol Valérie Cheynet Constance d’Aubarede Amélie Massardier-Pilonchery Marlyse Buisson Julien Lupo Bruno Pozzetto Pascal Poignard Bruno Lina Jean-Baptiste Fassier Florence Morfin Sophie Trouillet-Assant COVID-SER Study group |
| author_facet |
Antonin Bal Karen Brengel-Pesce Alexandre Gaymard Grégory Quéromès Nicolas Guibert Emile Frobert Maude Bouscambert Mary-Anne Trabaud Florence Allantaz-Frager Guy Oriol Valérie Cheynet Constance d’Aubarede Amélie Massardier-Pilonchery Marlyse Buisson Julien Lupo Bruno Pozzetto Pascal Poignard Bruno Lina Jean-Baptiste Fassier Florence Morfin Sophie Trouillet-Assant COVID-SER Study group |
| author_sort |
Antonin Bal |
| title |
Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study |
| title_short |
Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study |
| title_full |
Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study |
| title_fullStr |
Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study |
| title_full_unstemmed |
Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study |
| title_sort |
clinical and laboratory characteristics of symptomatic healthcare workers with suspected covid-19: a prospective cohort study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7f27f08771074336aabcecb066a0e25c |
| work_keys_str_mv |
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