Differential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function

Abstract We compared the effects of Heat-not-Burn cigarette (HNBC) to those of tobacco cigarette (Tcig), on myocardial, coronary and arterial function as well as on oxidative stress and platelet activation in 75 smokers. In the acute study, 50 smokers were randomised into smoking a single Tcig or a...

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Autores principales: Ignatios Ikonomidis, Dimitrios Vlastos, Gavriela Kostelli, Kallirhoe Kourea, Konstantinos Katogiannis, Maria Tsoumani, John Parissis, Ioanna Andreadou, Dimitrios Alexopoulos
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7f2ac1d85e3f4c8c931d1036e27887ac
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spelling oai:doaj.org-article:7f2ac1d85e3f4c8c931d1036e27887ac2021-12-02T17:51:13ZDifferential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function10.1038/s41598-021-91245-92045-2322https://doaj.org/article/7f2ac1d85e3f4c8c931d1036e27887ac2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91245-9https://doaj.org/toc/2045-2322Abstract We compared the effects of Heat-not-Burn cigarette (HNBC) to those of tobacco cigarette (Tcig), on myocardial, coronary and arterial function as well as on oxidative stress and platelet activation in 75 smokers. In the acute study, 50 smokers were randomised into smoking a single Tcig or a HNBC and after 60 min were crossed-over to the alternate smoking. For chronic phase, 50 smokers were switched to HNBC and were compared with an external group of 25 Tcig smokers before and after 1 month. Exhaled carbon monoxide (CO), pulse wave velocity (PWV), malondialdehyde (MDA) and thromboxane B2 (TxB2) were assessed in the acute and chronic study. Global longitudinal strain (GLS), myocardial work index (GWI), wasted myocardial work (GWW), coronary flow reserve (CFR), total arterial compliance (TAC) and flow-mediated dilation (FMD) were assessed in the chronic study. Acute HNBC smoking caused a smaller increase of PWV than Tcig (change 1.1 vs 0.54 m/s, p < 0.05) without change in CO and biomarkers in contrast to Tcig. Compared to Tcig, switching to HNBC for 1-month improved CO, FMD, CFR, TAC, GLS, GWW, MDA, TxB2 (differences 10.42 ppm, 4.3%, 0.98, 1.8 mL/mmHg, 2.35%, 19.72 mmHg%, 0.38 nmol/L and 45 pg/mL respectively, p < 0.05). HNBCs exert a less detrimental effect on vascular and cardiac function than tobacco cigarettes. Trial registration Registered on https://clinicaltrials.gov/ (NCT03452124, 02/03/2018).Ignatios IkonomidisDimitrios VlastosGavriela KostelliKallirhoe KoureaKonstantinos KatogiannisMaria TsoumaniJohn ParissisIoanna AndreadouDimitrios AlexopoulosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ignatios Ikonomidis
Dimitrios Vlastos
Gavriela Kostelli
Kallirhoe Kourea
Konstantinos Katogiannis
Maria Tsoumani
John Parissis
Ioanna Andreadou
Dimitrios Alexopoulos
Differential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function
description Abstract We compared the effects of Heat-not-Burn cigarette (HNBC) to those of tobacco cigarette (Tcig), on myocardial, coronary and arterial function as well as on oxidative stress and platelet activation in 75 smokers. In the acute study, 50 smokers were randomised into smoking a single Tcig or a HNBC and after 60 min were crossed-over to the alternate smoking. For chronic phase, 50 smokers were switched to HNBC and were compared with an external group of 25 Tcig smokers before and after 1 month. Exhaled carbon monoxide (CO), pulse wave velocity (PWV), malondialdehyde (MDA) and thromboxane B2 (TxB2) were assessed in the acute and chronic study. Global longitudinal strain (GLS), myocardial work index (GWI), wasted myocardial work (GWW), coronary flow reserve (CFR), total arterial compliance (TAC) and flow-mediated dilation (FMD) were assessed in the chronic study. Acute HNBC smoking caused a smaller increase of PWV than Tcig (change 1.1 vs 0.54 m/s, p < 0.05) without change in CO and biomarkers in contrast to Tcig. Compared to Tcig, switching to HNBC for 1-month improved CO, FMD, CFR, TAC, GLS, GWW, MDA, TxB2 (differences 10.42 ppm, 4.3%, 0.98, 1.8 mL/mmHg, 2.35%, 19.72 mmHg%, 0.38 nmol/L and 45 pg/mL respectively, p < 0.05). HNBCs exert a less detrimental effect on vascular and cardiac function than tobacco cigarettes. Trial registration Registered on https://clinicaltrials.gov/ (NCT03452124, 02/03/2018).
format article
author Ignatios Ikonomidis
Dimitrios Vlastos
Gavriela Kostelli
Kallirhoe Kourea
Konstantinos Katogiannis
Maria Tsoumani
John Parissis
Ioanna Andreadou
Dimitrios Alexopoulos
author_facet Ignatios Ikonomidis
Dimitrios Vlastos
Gavriela Kostelli
Kallirhoe Kourea
Konstantinos Katogiannis
Maria Tsoumani
John Parissis
Ioanna Andreadou
Dimitrios Alexopoulos
author_sort Ignatios Ikonomidis
title Differential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function
title_short Differential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function
title_full Differential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function
title_fullStr Differential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function
title_full_unstemmed Differential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function
title_sort differential effects of heat-not-burn and conventional cigarettes on coronary flow, myocardial and vascular function
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7f2ac1d85e3f4c8c931d1036e27887ac
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