Vascular involvement in systemic sclerosis (scleroderma)

Debendra Pattanaik1, Monica Brown2, Arnold E Postlethwaite11Division of Connective Tissue Diseases, Department of Medicine; 2Section of Pediatric Rheumatology Department of Pediatrics, University of Tennessee Health Science Center, and Department of Veterans Affairs Medical Center, Memphis, TN, USAA...

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Autores principales:	Pattanaik D, Brown M, Postlethwaite AE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7f2ad46947d94c52a6cd3a2d21f4600c
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spelling	oai:doaj.org-article:7f2ad46947d94c52a6cd3a2d21f4600c2021-12-02T00:13:23ZVascular involvement in systemic sclerosis (scleroderma)1178-7031https://doaj.org/article/7f2ad46947d94c52a6cd3a2d21f4600c2011-07-01T00:00:00Zhttp://www.dovepress.com/vascular-involvement-in-systemic-sclerosis-scleroderma-a7947https://doaj.org/toc/1178-7031Debendra Pattanaik1, Monica Brown2, Arnold E Postlethwaite11Division of Connective Tissue Diseases, Department of Medicine; 2Section of Pediatric Rheumatology Department of Pediatrics, University of Tennessee Health Science Center, and Department of Veterans Affairs Medical Center, Memphis, TN, USAAbstract: Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and pathogenesis of the systemic autoimmunity, fibrosis, and fibroproliferative vasculopathy are unknown and debated. In this review, the spectrum of vascular abnormalities and the options currently available to treat the vascular manifestations of SSc are discussed. Also discussed is how the hallmark pathologies (ie, how autoimmunity, vasculopathy, and fibrosis of the disease) might be effected and interconnected with modulatory input from lysophospholipids, sphingosine 1-phosphate, and lysophosphatidic acid.Keywords: fibrosis, autoimmunity, vasculopathy, S1P, LPAPattanaik DBrown MPostlethwaite AEDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2011, Iss default, Pp 105-125 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Pattanaik D Brown M Postlethwaite AE Vascular involvement in systemic sclerosis (scleroderma)
description	Debendra Pattanaik1, Monica Brown2, Arnold E Postlethwaite11Division of Connective Tissue Diseases, Department of Medicine; 2Section of Pediatric Rheumatology Department of Pediatrics, University of Tennessee Health Science Center, and Department of Veterans Affairs Medical Center, Memphis, TN, USAAbstract: Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and pathogenesis of the systemic autoimmunity, fibrosis, and fibroproliferative vasculopathy are unknown and debated. In this review, the spectrum of vascular abnormalities and the options currently available to treat the vascular manifestations of SSc are discussed. Also discussed is how the hallmark pathologies (ie, how autoimmunity, vasculopathy, and fibrosis of the disease) might be effected and interconnected with modulatory input from lysophospholipids, sphingosine 1-phosphate, and lysophosphatidic acid.Keywords: fibrosis, autoimmunity, vasculopathy, S1P, LPA
format	article
author	Pattanaik D Brown M Postlethwaite AE
author_facet	Pattanaik D Brown M Postlethwaite AE
author_sort	Pattanaik D
title	Vascular involvement in systemic sclerosis (scleroderma)
title_short	Vascular involvement in systemic sclerosis (scleroderma)
title_full	Vascular involvement in systemic sclerosis (scleroderma)
title_fullStr	Vascular involvement in systemic sclerosis (scleroderma)
title_full_unstemmed	Vascular involvement in systemic sclerosis (scleroderma)
title_sort	vascular involvement in systemic sclerosis (scleroderma)
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/7f2ad46947d94c52a6cd3a2d21f4600c
work_keys_str_mv	AT pattanaikd vascularinvolvementinsystemicsclerosisscleroderma AT brownm vascularinvolvementinsystemicsclerosisscleroderma AT postlethwaiteae vascularinvolvementinsystemicsclerosisscleroderma
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Vascular involvement in systemic sclerosis (scleroderma)

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