Technology update: bronchoscopic thermal vapor ablation for managing severe emphysema

Daniela Gompelmann,1,2 Ralf Eberhardt,1,2 Felix JF Herth1,21Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, 2German Center for Lung Research, Heidelberg, GermanyAbstract: Bronchoscopic thermal vapor ablation (BTVA) is an endoscopic lung volume reduction therapy that...

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Autores principales:	Gompelmann D, Eberhardt R, Herth FJF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/7f2cef541a5642acb37674f3dd863553
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spelling	oai:doaj.org-article:7f2cef541a5642acb37674f3dd8635532021-12-02T02:11:18ZTechnology update: bronchoscopic thermal vapor ablation for managing severe emphysema1179-1470https://doaj.org/article/7f2cef541a5642acb37674f3dd8635532014-09-01T00:00:00Zhttp://www.dovepress.com/technology-update-bronchoscopic-thermal-vapor-ablation-for-managing-se-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470 Daniela Gompelmann,1,2 Ralf Eberhardt,1,2 Felix JF Herth1,21Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, 2German Center for Lung Research, Heidelberg, GermanyAbstract: Bronchoscopic thermal vapor ablation (BTVA) is an endoscopic lung volume reduction therapy that presents an effective treatment approach in patients with severe upper lobe-predominant emphysema. By instillation of heated water vapor, an inflammatory reaction is induced, leading to fibrosis and scarring of the lung parenchyma, resulting in lobar volume reduction. Clinical single-arm trials demonstrated great outcomes, with significant improvement of lung function, exercise capacity, and quality of life. As the BTVA-induced local inflammatory response that seems to be essential for the desired lobar volume reduction can be associated with transient clinical worsening, strict monitoring of the patients is required. In future, the balance between efficacy and safety will constitute a major challenge. This review summarizes the BTVA procedure, the mechanism of action, and the results of the clinical trials, including the efficacy and safety data.Keywords: emphysema, bronchoscopy, bronchoscopic thermal vapor ablationGompelmann DEberhardt RHerth FJFDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2014, Iss default, Pp 335-341 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Gompelmann D Eberhardt R Herth FJF Technology update: bronchoscopic thermal vapor ablation for managing severe emphysema
description	Daniela Gompelmann,1,2 Ralf Eberhardt,1,2 Felix JF Herth1,21Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, 2German Center for Lung Research, Heidelberg, GermanyAbstract: Bronchoscopic thermal vapor ablation (BTVA) is an endoscopic lung volume reduction therapy that presents an effective treatment approach in patients with severe upper lobe-predominant emphysema. By instillation of heated water vapor, an inflammatory reaction is induced, leading to fibrosis and scarring of the lung parenchyma, resulting in lobar volume reduction. Clinical single-arm trials demonstrated great outcomes, with significant improvement of lung function, exercise capacity, and quality of life. As the BTVA-induced local inflammatory response that seems to be essential for the desired lobar volume reduction can be associated with transient clinical worsening, strict monitoring of the patients is required. In future, the balance between efficacy and safety will constitute a major challenge. This review summarizes the BTVA procedure, the mechanism of action, and the results of the clinical trials, including the efficacy and safety data.Keywords: emphysema, bronchoscopy, bronchoscopic thermal vapor ablation
format	article
author	Gompelmann D Eberhardt R Herth FJF
author_facet	Gompelmann D Eberhardt R Herth FJF
author_sort	Gompelmann D
title	Technology update: bronchoscopic thermal vapor ablation for managing severe emphysema
title_short	Technology update: bronchoscopic thermal vapor ablation for managing severe emphysema
title_full	Technology update: bronchoscopic thermal vapor ablation for managing severe emphysema
title_fullStr	Technology update: bronchoscopic thermal vapor ablation for managing severe emphysema
title_full_unstemmed	Technology update: bronchoscopic thermal vapor ablation for managing severe emphysema
title_sort	technology update: bronchoscopic thermal vapor ablation for managing severe emphysema
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/7f2cef541a5642acb37674f3dd863553
work_keys_str_mv	AT gompelmannd technologyupdatebronchoscopicthermalvaporablationformanagingsevereemphysema AT eberhardtr technologyupdatebronchoscopicthermalvaporablationformanagingsevereemphysema AT herthfjf technologyupdatebronchoscopicthermalvaporablationformanagingsevereemphysema
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Technology update: bronchoscopic thermal vapor ablation for managing severe emphysema

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