Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics

Leukaemic stem cells drive acute myeloid leukaemia (AML) progression and relapse but they are incompletely characterized. Here, the authors combine single-cell transcriptomics and clonal tracking using nuclear and mitochondrial somatic variants to distinguish healthy, pre-leukaemic and leukaemic ste...

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Autores principales: Lars Velten, Benjamin A. Story, Pablo Hernández-Malmierca, Simon Raffel, Daniel R. Leonce, Jennifer Milbank, Malte Paulsen, Aykut Demir, Chelsea Szu-Tu, Robert Frömel, Christoph Lutz, Daniel Nowak, Johann-Christoph Jann, Caroline Pabst, Tobias Boch, Wolf-Karsten Hofmann, Carsten Müller-Tidow, Andreas Trumpp, Simon Haas, Lars M. Steinmetz
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7f3244539bc54da0bc5ec3fba0f6edbe
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spelling oai:doaj.org-article:7f3244539bc54da0bc5ec3fba0f6edbe2021-12-02T13:33:09ZIdentification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics10.1038/s41467-021-21650-12041-1723https://doaj.org/article/7f3244539bc54da0bc5ec3fba0f6edbe2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21650-1https://doaj.org/toc/2041-1723Leukaemic stem cells drive acute myeloid leukaemia (AML) progression and relapse but they are incompletely characterized. Here, the authors combine single-cell transcriptomics and clonal tracking using nuclear and mitochondrial somatic variants to distinguish healthy, pre-leukaemic and leukaemic stem cells in AML.Lars VeltenBenjamin A. StoryPablo Hernández-MalmiercaSimon RaffelDaniel R. LeonceJennifer MilbankMalte PaulsenAykut DemirChelsea Szu-TuRobert FrömelChristoph LutzDaniel NowakJohann-Christoph JannCaroline PabstTobias BochWolf-Karsten HofmannCarsten Müller-TidowAndreas TrumppSimon HaasLars M. SteinmetzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lars Velten
Benjamin A. Story
Pablo Hernández-Malmierca
Simon Raffel
Daniel R. Leonce
Jennifer Milbank
Malte Paulsen
Aykut Demir
Chelsea Szu-Tu
Robert Frömel
Christoph Lutz
Daniel Nowak
Johann-Christoph Jann
Caroline Pabst
Tobias Boch
Wolf-Karsten Hofmann
Carsten Müller-Tidow
Andreas Trumpp
Simon Haas
Lars M. Steinmetz
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
description Leukaemic stem cells drive acute myeloid leukaemia (AML) progression and relapse but they are incompletely characterized. Here, the authors combine single-cell transcriptomics and clonal tracking using nuclear and mitochondrial somatic variants to distinguish healthy, pre-leukaemic and leukaemic stem cells in AML.
format article
author Lars Velten
Benjamin A. Story
Pablo Hernández-Malmierca
Simon Raffel
Daniel R. Leonce
Jennifer Milbank
Malte Paulsen
Aykut Demir
Chelsea Szu-Tu
Robert Frömel
Christoph Lutz
Daniel Nowak
Johann-Christoph Jann
Caroline Pabst
Tobias Boch
Wolf-Karsten Hofmann
Carsten Müller-Tidow
Andreas Trumpp
Simon Haas
Lars M. Steinmetz
author_facet Lars Velten
Benjamin A. Story
Pablo Hernández-Malmierca
Simon Raffel
Daniel R. Leonce
Jennifer Milbank
Malte Paulsen
Aykut Demir
Chelsea Szu-Tu
Robert Frömel
Christoph Lutz
Daniel Nowak
Johann-Christoph Jann
Caroline Pabst
Tobias Boch
Wolf-Karsten Hofmann
Carsten Müller-Tidow
Andreas Trumpp
Simon Haas
Lars M. Steinmetz
author_sort Lars Velten
title Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
title_short Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
title_full Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
title_fullStr Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
title_full_unstemmed Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
title_sort identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7f3244539bc54da0bc5ec3fba0f6edbe
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