Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics

Leukaemic stem cells drive acute myeloid leukaemia (AML) progression and relapse but they are incompletely characterized. Here, the authors combine single-cell transcriptomics and clonal tracking using nuclear and mitochondrial somatic variants to distinguish healthy, pre-leukaemic and leukaemic ste...

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Main Authors: Lars Velten, Benjamin A. Story, Pablo Hernández-Malmierca, Simon Raffel, Daniel R. Leonce, Jennifer Milbank, Malte Paulsen, Aykut Demir, Chelsea Szu-Tu, Robert Frömel, Christoph Lutz, Daniel Nowak, Johann-Christoph Jann, Caroline Pabst, Tobias Boch, Wolf-Karsten Hofmann, Carsten Müller-Tidow, Andreas Trumpp, Simon Haas, Lars M. Steinmetz
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/7f3244539bc54da0bc5ec3fba0f6edbe
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https://doaj.org/article/7f3244539bc54da0bc5ec3fba0f6edbe

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