The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia

Getinet Kumie, Tadele Melak, Habtamu Wondifraw Baynes University of Gondar, College of Medicine & Health Sciences, School of Biomedical & Laboratory Sciences, Department of Clinical Chemistry, Gondar, EthiopiaCorrespondence: Habtamu Wondifraw BaynesUniversity of Gondar, College of Me...

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Autores principales:	Kumie G, Melak T, Wondifraw Baynes H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	breast cancer lipid profile women ethiopia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7f359cb63a054d6fbeb0be9be91087b4
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spelling	oai:doaj.org-article:7f359cb63a054d6fbeb0be9be91087b42021-12-02T11:45:06ZThe Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia1179-1314https://doaj.org/article/7f359cb63a054d6fbeb0be9be91087b42020-12-01T00:00:00Zhttps://www.dovepress.com/the-association-of-serum-lipid-levels-with-breast-cancer-risks-among-w-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Getinet Kumie, Tadele Melak, Habtamu Wondifraw Baynes University of Gondar, College of Medicine & Health Sciences, School of Biomedical & Laboratory Sciences, Department of Clinical Chemistry, Gondar, EthiopiaCorrespondence: Habtamu Wondifraw BaynesUniversity of Gondar, College of Medicine & Health Sciences, School of Biomedical & Laboratory Sciences, Department of Clinical Chemistry, P.O. Box: 196, Gondar, EthiopiaEmail Habtamuw97@gmail.comBackground: Breast cancer is a malignant condition affecting about 2.1 million women worldwide. Cancer cells have increased the level of cholesterol and facilitate lipid biosynthesis and metabolism. Therefore, there is a need for assessment of serum lipid and its association with breast cancer risks.Methods: A comparative cross-sectional study was conducted among women with breast cancer (n=23), benign breast lump (n=68) and apparently healthy control (n=91) at Felege Hiwot Comprehensive Specialized Hospital, from January to May, 2020. A convenient sampling technique and an interviewer-administered questionnaires were used to collect data. Five milliliter of fasting blood sample was collected for lipid level analysis using enzymatic colorimetric method. Data entry and analysis were done using Epi Info version 7 and SPSS version 20. One way ANOVA and logistic regression were the tools used for analysis, and a p-value of < 0.05 was considered as statistically significant.Results: The mean age of healthy control, benign and malignant breast cancer was 32.51± 9.44, 33.34± 10.664 and 37.65± 14.345 years, respectively. The mean serum value of TG among controls, benign and malignant women was 168.67± 41.616, 170.1± 59.018 and 211.7± 82.924 (p< 0.001), respectively. The mean serum concentration of HDL-c was significantly different between the three groups (47.61± 9.122, 44.69± 14.479 and 38.26± 7.442: p=0.004) among controls, benign and malignant, respectively. Low serum HDL-c level was significantly associated with age at parity (AOR=3.353; 95% CI=1.33, 8.436), the habit of drinking alcohol (AOR=2.125; 95% CI=1.065, 4.241) and BMI (AOR=3.555; 95% CI=1.13, 11.184). In addition, BMI (AOR: 4.54; 95% CI: 1.45, 14.21) was statistically associated with high LDL-c level.Conclusion: The overall prevalence of dyslipidemia was high in breast cancer patients. Age at first parity, alcohol consumption and BMI were significantly associated with low serum HDL-c level.Keywords: breast cancer, lipid profile, women, EthiopiaKumie GMelak TWondifraw Baynes HDove Medical Pressarticlebreast cancerlipid profilewomenethiopiaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 12, Pp 279-287 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer lipid profile women ethiopia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer lipid profile women ethiopia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kumie G Melak T Wondifraw Baynes H The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia
description	Getinet Kumie, Tadele Melak, Habtamu Wondifraw Baynes University of Gondar, College of Medicine & Health Sciences, School of Biomedical & Laboratory Sciences, Department of Clinical Chemistry, Gondar, EthiopiaCorrespondence: Habtamu Wondifraw BaynesUniversity of Gondar, College of Medicine & Health Sciences, School of Biomedical & Laboratory Sciences, Department of Clinical Chemistry, P.O. Box: 196, Gondar, EthiopiaEmail Habtamuw97@gmail.comBackground: Breast cancer is a malignant condition affecting about 2.1 million women worldwide. Cancer cells have increased the level of cholesterol and facilitate lipid biosynthesis and metabolism. Therefore, there is a need for assessment of serum lipid and its association with breast cancer risks.Methods: A comparative cross-sectional study was conducted among women with breast cancer (n=23), benign breast lump (n=68) and apparently healthy control (n=91) at Felege Hiwot Comprehensive Specialized Hospital, from January to May, 2020. A convenient sampling technique and an interviewer-administered questionnaires were used to collect data. Five milliliter of fasting blood sample was collected for lipid level analysis using enzymatic colorimetric method. Data entry and analysis were done using Epi Info version 7 and SPSS version 20. One way ANOVA and logistic regression were the tools used for analysis, and a p-value of < 0.05 was considered as statistically significant.Results: The mean age of healthy control, benign and malignant breast cancer was 32.51± 9.44, 33.34± 10.664 and 37.65± 14.345 years, respectively. The mean serum value of TG among controls, benign and malignant women was 168.67± 41.616, 170.1± 59.018 and 211.7± 82.924 (p< 0.001), respectively. The mean serum concentration of HDL-c was significantly different between the three groups (47.61± 9.122, 44.69± 14.479 and 38.26± 7.442: p=0.004) among controls, benign and malignant, respectively. Low serum HDL-c level was significantly associated with age at parity (AOR=3.353; 95% CI=1.33, 8.436), the habit of drinking alcohol (AOR=2.125; 95% CI=1.065, 4.241) and BMI (AOR=3.555; 95% CI=1.13, 11.184). In addition, BMI (AOR: 4.54; 95% CI: 1.45, 14.21) was statistically associated with high LDL-c level.Conclusion: The overall prevalence of dyslipidemia was high in breast cancer patients. Age at first parity, alcohol consumption and BMI were significantly associated with low serum HDL-c level.Keywords: breast cancer, lipid profile, women, Ethiopia
format	article
author	Kumie G Melak T Wondifraw Baynes H
author_facet	Kumie G Melak T Wondifraw Baynes H
author_sort	Kumie G
title	The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia
title_short	The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia
title_full	The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia
title_fullStr	The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia
title_full_unstemmed	The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia
title_sort	association of serum lipid levels with breast cancer risks among women with breast cancer at felege hiwot comprehensive specialized hospital, northwest ethiopia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/7f359cb63a054d6fbeb0be9be91087b4
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The Association of Serum Lipid Levels with Breast Cancer Risks Among Women with Breast Cancer at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia

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