Value of Patlak Ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis

Abstract The association between 18F-fluorodeoxyglucose (18F-FDG) myocardial uptake and clinical presentations in cardiac sarcoidosis (CS) has not yet been clarified. The Patlak slope, Ki, which represents the rate of 18F-FDG uptake is a quantitative index of 18F-FDG metabolism. This study aims to i...

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Autores principales:	Masatoyo Nakajo, Satoko Ojima, Hirofumi Kawakami, Atsushi Tani, Akira Hirayama, Megumi Jinguji, Takuro Kubozono, Mitsuru Ohishi, Takashi Yoshiura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f3641ec6573453cafede21f38113e7c
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spelling	oai:doaj.org-article:7f3641ec6573453cafede21f38113e7c2021-12-02T14:06:50ZValue of Patlak Ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis10.1038/s41598-021-82217-02045-2322https://doaj.org/article/7f3641ec6573453cafede21f38113e7c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82217-0https://doaj.org/toc/2045-2322Abstract The association between 18F-fluorodeoxyglucose (18F-FDG) myocardial uptake and clinical presentations in cardiac sarcoidosis (CS) has not yet been clarified. The Patlak slope, Ki, which represents the rate of 18F-FDG uptake is a quantitative index of 18F-FDG metabolism. This study aims to investigate the usefulness of standardized uptake value (SUV) and Patlak Ki images (Ki images) extracted from dynamic 18F-FDG-PET/CT for evaluating the risk of clinical events (CEs) in CS. The SUV and Ki myocardial images were generated from 30 dynamic 18F-FDG-PET/CT scans of 21 CS patients. The SUV and Ki images both were rated as positive in 19 scans and negative in 11 scans with the same incidence of CEs which were significantly higher in positive than negative scans [cardiac dysfunction: 78.9% (15/19) vs. 27.2% (3/11); arrhythmic events: 65.5% (10/19) vs. 0% (0/11)]. In 19 positive scans, the three Ki parameters (Ki max, Ki mean and Ki volume) were significantly higher in scans for patients with arrhythmic events than in those without. Logistic regression analysis showed that the Ki volume alone was significantly associated with the risk of arrhythmic events. Our study suggests that Ki images may add value to SUV images for evaluating the risk of CEs in CS patients.Masatoyo NakajoSatoko OjimaHirofumi KawakamiAtsushi TaniAkira HirayamaMegumi JingujiTakuro KubozonoMitsuru OhishiTakashi YoshiuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masatoyo Nakajo Satoko Ojima Hirofumi Kawakami Atsushi Tani Akira Hirayama Megumi Jinguji Takuro Kubozono Mitsuru Ohishi Takashi Yoshiura Value of Patlak Ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
description	Abstract The association between 18F-fluorodeoxyglucose (18F-FDG) myocardial uptake and clinical presentations in cardiac sarcoidosis (CS) has not yet been clarified. The Patlak slope, Ki, which represents the rate of 18F-FDG uptake is a quantitative index of 18F-FDG metabolism. This study aims to investigate the usefulness of standardized uptake value (SUV) and Patlak Ki images (Ki images) extracted from dynamic 18F-FDG-PET/CT for evaluating the risk of clinical events (CEs) in CS. The SUV and Ki myocardial images were generated from 30 dynamic 18F-FDG-PET/CT scans of 21 CS patients. The SUV and Ki images both were rated as positive in 19 scans and negative in 11 scans with the same incidence of CEs which were significantly higher in positive than negative scans [cardiac dysfunction: 78.9% (15/19) vs. 27.2% (3/11); arrhythmic events: 65.5% (10/19) vs. 0% (0/11)]. In 19 positive scans, the three Ki parameters (Ki max, Ki mean and Ki volume) were significantly higher in scans for patients with arrhythmic events than in those without. Logistic regression analysis showed that the Ki volume alone was significantly associated with the risk of arrhythmic events. Our study suggests that Ki images may add value to SUV images for evaluating the risk of CEs in CS patients.
format	article
author	Masatoyo Nakajo Satoko Ojima Hirofumi Kawakami Atsushi Tani Akira Hirayama Megumi Jinguji Takuro Kubozono Mitsuru Ohishi Takashi Yoshiura
author_facet	Masatoyo Nakajo Satoko Ojima Hirofumi Kawakami Atsushi Tani Akira Hirayama Megumi Jinguji Takuro Kubozono Mitsuru Ohishi Takashi Yoshiura
author_sort	Masatoyo Nakajo
title	Value of Patlak Ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_short	Value of Patlak Ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_full	Value of Patlak Ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_fullStr	Value of Patlak Ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_full_unstemmed	Value of Patlak Ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
title_sort	value of patlak ki images from 18f-fdg-pet/ct for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7f3641ec6573453cafede21f38113e7c
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Value of Patlak Ki images from 18F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis

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