Tailoring protein nanomechanics with chemical reactivity

Post-translational modifications modulate nanomechanics of proteins. Here the authors use single-molecule force-clamp spectroscopy supported by density functional theory calculations to show how reactive low-weight molecular thiol compounds directly affect mechanical protein folding.

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Autores principales:	Amy E. M. Beedle, Marc Mora, Steven Lynham, Guillaume Stirnemann, Sergi Garcia-Manyes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f39aa321a0a4c9e85b067804b4cb304
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spelling	oai:doaj.org-article:7f39aa321a0a4c9e85b067804b4cb3042021-12-02T15:37:06ZTailoring protein nanomechanics with chemical reactivity10.1038/ncomms156582041-1723https://doaj.org/article/7f39aa321a0a4c9e85b067804b4cb3042017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15658https://doaj.org/toc/2041-1723Post-translational modifications modulate nanomechanics of proteins. Here the authors use single-molecule force-clamp spectroscopy supported by density functional theory calculations to show how reactive low-weight molecular thiol compounds directly affect mechanical protein folding.Amy E. M. BeedleMarc MoraSteven LynhamGuillaume StirnemannSergi Garcia-ManyesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy E. M. Beedle Marc Mora Steven Lynham Guillaume Stirnemann Sergi Garcia-Manyes Tailoring protein nanomechanics with chemical reactivity
description	Post-translational modifications modulate nanomechanics of proteins. Here the authors use single-molecule force-clamp spectroscopy supported by density functional theory calculations to show how reactive low-weight molecular thiol compounds directly affect mechanical protein folding.
format	article
author	Amy E. M. Beedle Marc Mora Steven Lynham Guillaume Stirnemann Sergi Garcia-Manyes
author_facet	Amy E. M. Beedle Marc Mora Steven Lynham Guillaume Stirnemann Sergi Garcia-Manyes
author_sort	Amy E. M. Beedle
title	Tailoring protein nanomechanics with chemical reactivity
title_short	Tailoring protein nanomechanics with chemical reactivity
title_full	Tailoring protein nanomechanics with chemical reactivity
title_fullStr	Tailoring protein nanomechanics with chemical reactivity
title_full_unstemmed	Tailoring protein nanomechanics with chemical reactivity
title_sort	tailoring protein nanomechanics with chemical reactivity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7f39aa321a0a4c9e85b067804b4cb304
work_keys_str_mv	AT amyembeedle tailoringproteinnanomechanicswithchemicalreactivity AT marcmora tailoringproteinnanomechanicswithchemicalreactivity AT stevenlynham tailoringproteinnanomechanicswithchemicalreactivity AT guillaumestirnemann tailoringproteinnanomechanicswithchemicalreactivity AT sergigarciamanyes tailoringproteinnanomechanicswithchemicalreactivity
_version_	1718386242700181504

Tailoring protein nanomechanics with chemical reactivity

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