Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold

This paper proposes the bio-fabrication of a porous scaffold from a selection procedure of elements taking into account biological behavior, using magnesium (Mg) alloyed with calcium (Ca) and zinc (Zn). The proposed scaffold could work as a treatment for specific pathologies in trauma and oncology,...

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Autores principales:	Luis Humberto Campos Becerra, Alejandro Torres Castro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	porous magnesium scaffold casting of Mg base alloys morphological characterization cell viability micro-indentation toxicity Crystallography QD901-999
Acceso en línea:	https://doaj.org/article/7f3e6d5ae04f43318137916c95fbf815
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spelling	oai:doaj.org-article:7f3e6d5ae04f43318137916c95fbf8152021-11-25T17:19:35ZBio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold10.3390/cryst111114162073-4352https://doaj.org/article/7f3e6d5ae04f43318137916c95fbf8152021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4352/11/11/1416https://doaj.org/toc/2073-4352This paper proposes the bio-fabrication of a porous scaffold from a selection procedure of elements taking into account biological behavior, using magnesium (Mg) alloyed with calcium (Ca) and zinc (Zn). The proposed scaffold could work as a treatment for specific pathologies in trauma and oncology, on the one hand, in addition to possible applications in osteosynthesis, through contrib-uting to osseointegration and infection control through the release of drugs. Finally, another pos-sible attribute of this alloy could be its use as a complementary treatment for osteosarcoma; this is due to the basification produced by oxidative degradation (attack on cancer cells). The evaluation of cell viability of an alloy of Mg - 25 wt% Ca - 5 wt% Zn will strengthen current perspectives on the use of Mg in the clinical evaluation of various treatments in trauma and oncology. Considera-tions on the preparation of an alloy of Mg - 25 wt% Ca - 5 wt% Zn and its morphological charac-terization will help researchers understand its applicability for the development of new surgical techniques and lead to a deeper investigation of alternative treatments. However, it is very im-portant to bear in mind the mechanical effect of elements such as Ca and Zn on the degradation of the alloy matrix; the best alternative to predict the biological-mechanical potential starts with the selection of the essential-nutritional elements and their mechanical evaluation by mi-cro-indentation due to the fragility of the matrix. Therefore, the morphological evaluation of the specimens of Mg - 25 wt% Ca - 5 wt% Zn will show the crystallinity of the alloy; these results to-gether contribute to the design of biomedical alloys for use in treatments for various medical spe-cialties. The results indicated that cell viability is not affected, and there are no morphological changes in the cells.Luis Humberto Campos BecerraAlejandro Torres CastroMDPI AGarticleporous magnesium scaffoldcasting of Mg base alloysmorphological characterizationcell viabilitymicro-indentationtoxicityCrystallographyQD901-999ENCrystals, Vol 11, Iss 1416, p 1416 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	porous magnesium scaffold casting of Mg base alloys morphological characterization cell viability micro-indentation toxicity Crystallography QD901-999
spellingShingle	porous magnesium scaffold casting of Mg base alloys morphological characterization cell viability micro-indentation toxicity Crystallography QD901-999 Luis Humberto Campos Becerra Alejandro Torres Castro Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold
description	This paper proposes the bio-fabrication of a porous scaffold from a selection procedure of elements taking into account biological behavior, using magnesium (Mg) alloyed with calcium (Ca) and zinc (Zn). The proposed scaffold could work as a treatment for specific pathologies in trauma and oncology, on the one hand, in addition to possible applications in osteosynthesis, through contrib-uting to osseointegration and infection control through the release of drugs. Finally, another pos-sible attribute of this alloy could be its use as a complementary treatment for osteosarcoma; this is due to the basification produced by oxidative degradation (attack on cancer cells). The evaluation of cell viability of an alloy of Mg - 25 wt% Ca - 5 wt% Zn will strengthen current perspectives on the use of Mg in the clinical evaluation of various treatments in trauma and oncology. Considera-tions on the preparation of an alloy of Mg - 25 wt% Ca - 5 wt% Zn and its morphological charac-terization will help researchers understand its applicability for the development of new surgical techniques and lead to a deeper investigation of alternative treatments. However, it is very im-portant to bear in mind the mechanical effect of elements such as Ca and Zn on the degradation of the alloy matrix; the best alternative to predict the biological-mechanical potential starts with the selection of the essential-nutritional elements and their mechanical evaluation by mi-cro-indentation due to the fragility of the matrix. Therefore, the morphological evaluation of the specimens of Mg - 25 wt% Ca - 5 wt% Zn will show the crystallinity of the alloy; these results to-gether contribute to the design of biomedical alloys for use in treatments for various medical spe-cialties. The results indicated that cell viability is not affected, and there are no morphological changes in the cells.
format	article
author	Luis Humberto Campos Becerra Alejandro Torres Castro
author_facet	Luis Humberto Campos Becerra Alejandro Torres Castro
author_sort	Luis Humberto Campos Becerra
title	Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold
title_short	Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold
title_full	Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold
title_fullStr	Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold
title_full_unstemmed	Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold
title_sort	bio-fabrication and experimental validation of an mg - 25ca - 5zn alloy proposed for a porous metallic scaffold
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7f3e6d5ae04f43318137916c95fbf815
work_keys_str_mv	AT luishumbertocamposbecerra biofabricationandexperimentalvalidationofanmg25ca5znalloyproposedforaporousmetallicscaffold AT alejandrotorrescastro biofabricationandexperimentalvalidationofanmg25ca5znalloyproposedforaporousmetallicscaffold
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Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold

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