Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction

Phase separation has been suggested as a mechanism for heterochromatin formation through condensation of heterochromatin-associated factors. Here the authors show Polycomb complex PRC1 forms condensates on chromatin. Using optogenetic tools they nucleate local Polycomb condensates to show that this...

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Autores principales:	Jorine M. Eeftens, Manya Kapoor, Davide Michieletto, Clifford P. Brangwynne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7f452b896dc54166b408650ee691f243
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spelling	oai:doaj.org-article:7f452b896dc54166b408650ee691f2432021-12-02T19:16:33ZPolycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction10.1038/s41467-021-26147-52041-1723https://doaj.org/article/7f452b896dc54166b408650ee691f2432021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26147-5https://doaj.org/toc/2041-1723Phase separation has been suggested as a mechanism for heterochromatin formation through condensation of heterochromatin-associated factors. Here the authors show Polycomb complex PRC1 forms condensates on chromatin. Using optogenetic tools they nucleate local Polycomb condensates to show that this phase separation leads to subsequent histone modifications and chromatin compaction.Jorine M. EeftensManya KapoorDavide MichielettoClifford P. BrangwynneNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jorine M. Eeftens Manya Kapoor Davide Michieletto Clifford P. Brangwynne Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction
description	Phase separation has been suggested as a mechanism for heterochromatin formation through condensation of heterochromatin-associated factors. Here the authors show Polycomb complex PRC1 forms condensates on chromatin. Using optogenetic tools they nucleate local Polycomb condensates to show that this phase separation leads to subsequent histone modifications and chromatin compaction.
format	article
author	Jorine M. Eeftens Manya Kapoor Davide Michieletto Clifford P. Brangwynne
author_facet	Jorine M. Eeftens Manya Kapoor Davide Michieletto Clifford P. Brangwynne
author_sort	Jorine M. Eeftens
title	Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction
title_short	Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction
title_full	Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction
title_fullStr	Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction
title_full_unstemmed	Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction
title_sort	polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7f452b896dc54166b408650ee691f243
work_keys_str_mv	AT jorinemeeftens polycombcondensatescanpromoteepigeneticmarksbutarenotrequiredforsustainedchromatincompaction AT manyakapoor polycombcondensatescanpromoteepigeneticmarksbutarenotrequiredforsustainedchromatincompaction AT davidemichieletto polycombcondensatescanpromoteepigeneticmarksbutarenotrequiredforsustainedchromatincompaction AT cliffordpbrangwynne polycombcondensatescanpromoteepigeneticmarksbutarenotrequiredforsustainedchromatincompaction
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Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction

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