Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction

Phase separation has been suggested as a mechanism for heterochromatin formation through condensation of heterochromatin-associated factors. Here the authors show Polycomb complex PRC1 forms condensates on chromatin. Using optogenetic tools they nucleate local Polycomb condensates to show that this...

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Autores principales: Jorine M. Eeftens, Manya Kapoor, Davide Michieletto, Clifford P. Brangwynne
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7f452b896dc54166b408650ee691f243
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