The mechanical properties of individual cell spheroids

Abstract The overall physical properties of tissues emerge in a complex manner from the properties of the component cells and other constituent materials from which the tissue is formed, across multiple length scales ranging from nanometres to millimetres. Recent studies have suggested that interfac...

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Autores principales:	Alice Blumlein, Noel Williams, Jennifer J. McManus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7f4599c16c6c42f8b1fd0655ecbe1c91
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spelling	oai:doaj.org-article:7f4599c16c6c42f8b1fd0655ecbe1c912021-12-02T16:08:23ZThe mechanical properties of individual cell spheroids10.1038/s41598-017-07813-52045-2322https://doaj.org/article/7f4599c16c6c42f8b1fd0655ecbe1c912017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07813-5https://doaj.org/toc/2045-2322Abstract The overall physical properties of tissues emerge in a complex manner from the properties of the component cells and other constituent materials from which the tissue is formed, across multiple length scales ranging from nanometres to millimetres. Recent studies have suggested that interfacial tension between cells contributes significantly to the mechanical properties of tissues and that the overall surface tension is determined by the ratio of adhesion tension to cortical tension. Using cavitation rheology (CR), we have measured the interfacial properties and the elastic modulus of spheroids formed from HEK cells. By comparing the work of bubble formation with deformation of the cell spheroid at different length scales, we have estimated the cortical tension for HEK cells. This innovative approach to understanding the fundamental physical properties associated with tissue mechanics may guide new approaches for the generation of materials to replace or regenerate damaged or diseased tissues.Alice BlumleinNoel WilliamsJennifer J. McManusNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alice Blumlein Noel Williams Jennifer J. McManus The mechanical properties of individual cell spheroids
description	Abstract The overall physical properties of tissues emerge in a complex manner from the properties of the component cells and other constituent materials from which the tissue is formed, across multiple length scales ranging from nanometres to millimetres. Recent studies have suggested that interfacial tension between cells contributes significantly to the mechanical properties of tissues and that the overall surface tension is determined by the ratio of adhesion tension to cortical tension. Using cavitation rheology (CR), we have measured the interfacial properties and the elastic modulus of spheroids formed from HEK cells. By comparing the work of bubble formation with deformation of the cell spheroid at different length scales, we have estimated the cortical tension for HEK cells. This innovative approach to understanding the fundamental physical properties associated with tissue mechanics may guide new approaches for the generation of materials to replace or regenerate damaged or diseased tissues.
format	article
author	Alice Blumlein Noel Williams Jennifer J. McManus
author_facet	Alice Blumlein Noel Williams Jennifer J. McManus
author_sort	Alice Blumlein
title	The mechanical properties of individual cell spheroids
title_short	The mechanical properties of individual cell spheroids
title_full	The mechanical properties of individual cell spheroids
title_fullStr	The mechanical properties of individual cell spheroids
title_full_unstemmed	The mechanical properties of individual cell spheroids
title_sort	mechanical properties of individual cell spheroids
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7f4599c16c6c42f8b1fd0655ecbe1c91
work_keys_str_mv	AT aliceblumlein themechanicalpropertiesofindividualcellspheroids AT noelwilliams themechanicalpropertiesofindividualcellspheroids AT jenniferjmcmanus themechanicalpropertiesofindividualcellspheroids AT aliceblumlein mechanicalpropertiesofindividualcellspheroids AT noelwilliams mechanicalpropertiesofindividualcellspheroids AT jenniferjmcmanus mechanicalpropertiesofindividualcellspheroids
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The mechanical properties of individual cell spheroids

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