Vitamin D receptor gene polymorphisms in atopy

Abstract Background The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases....

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Autores principales:	Laura Tamasauskiene, Ieva Golubickaite, Rasa Ugenskiene, Nikolajs Sjakste, Natalia Paramonova, Lawrence Shih‐Hsin Wu, Lawrence Shih‐Jiu‐Yao Wang, Brigita Sitkauskiene
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	atopy VDR vitamin D Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7f4ceebd969d484a93ab9586fa889448
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spelling	oai:doaj.org-article:7f4ceebd969d484a93ab9586fa8894482021-11-12T19:57:14ZVitamin D receptor gene polymorphisms in atopy2050-452710.1002/iid3.487https://doaj.org/article/7f4ceebd969d484a93ab9586fa8894482021-12-01T00:00:00Zhttps://doi.org/10.1002/iid3.487https://doaj.org/toc/2050-4527Abstract Background The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases. Aims This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy. Methods & Materials We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients. Results We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. There is evidence that vitamin D may be associated with anti‐inflammatory effects in allergic diseases. Some of VDR polymorphisms also may play a role in pathogenesis of these diseases. However, the data from different studies are controversial. Discussion The results of different studies are usually inconsistent, most probably due to populational bias or differences in methodology. Even though, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases, especially atopic dermatitis, and asthma. Conclusions There is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases.Laura TamasauskieneIeva GolubickaiteRasa UgenskieneNikolajs SjaksteNatalia ParamonovaLawrence Shih‐Hsin WuLawrence Shih‐Jiu‐Yao WangBrigita SitkauskieneWileyarticleatopyVDRvitamin DImmunologic diseases. AllergyRC581-607ENImmunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1153-1159 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopy VDR vitamin D Immunologic diseases. Allergy RC581-607
spellingShingle	atopy VDR vitamin D Immunologic diseases. Allergy RC581-607 Laura Tamasauskiene Ieva Golubickaite Rasa Ugenskiene Nikolajs Sjakste Natalia Paramonova Lawrence Shih‐Hsin Wu Lawrence Shih‐Jiu‐Yao Wang Brigita Sitkauskiene Vitamin D receptor gene polymorphisms in atopy
description	Abstract Background The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases. Aims This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy. Methods & Materials We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients. Results We noticed that levels of vitamin D are extensively studied in atopy by many research groups, however, polymorphisms of vitamin D receptor gene and their link with levels of vitamin D lack comprehensive data. There is evidence that vitamin D may be associated with anti‐inflammatory effects in allergic diseases. Some of VDR polymorphisms also may play a role in pathogenesis of these diseases. However, the data from different studies are controversial. Discussion The results of different studies are usually inconsistent, most probably due to populational bias or differences in methodology. Even though, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases, especially atopic dermatitis, and asthma. Conclusions There is controversial data about the level of vitamin D and its role in atopy; however, more evidence shows a positive impact on the risk and outcomes of allergic diseases.
format	article
author	Laura Tamasauskiene Ieva Golubickaite Rasa Ugenskiene Nikolajs Sjakste Natalia Paramonova Lawrence Shih‐Hsin Wu Lawrence Shih‐Jiu‐Yao Wang Brigita Sitkauskiene
author_facet	Laura Tamasauskiene Ieva Golubickaite Rasa Ugenskiene Nikolajs Sjakste Natalia Paramonova Lawrence Shih‐Hsin Wu Lawrence Shih‐Jiu‐Yao Wang Brigita Sitkauskiene
author_sort	Laura Tamasauskiene
title	Vitamin D receptor gene polymorphisms in atopy
title_short	Vitamin D receptor gene polymorphisms in atopy
title_full	Vitamin D receptor gene polymorphisms in atopy
title_fullStr	Vitamin D receptor gene polymorphisms in atopy
title_full_unstemmed	Vitamin D receptor gene polymorphisms in atopy
title_sort	vitamin d receptor gene polymorphisms in atopy
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/7f4ceebd969d484a93ab9586fa889448
work_keys_str_mv	AT lauratamasauskiene vitamindreceptorgenepolymorphismsinatopy AT ievagolubickaite vitamindreceptorgenepolymorphismsinatopy AT rasaugenskiene vitamindreceptorgenepolymorphismsinatopy AT nikolajssjakste vitamindreceptorgenepolymorphismsinatopy AT nataliaparamonova vitamindreceptorgenepolymorphismsinatopy AT lawrenceshihhsinwu vitamindreceptorgenepolymorphismsinatopy AT lawrenceshihjiuyaowang vitamindreceptorgenepolymorphismsinatopy AT brigitasitkauskiene vitamindreceptorgenepolymorphismsinatopy
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Vitamin D receptor gene polymorphisms in atopy

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