CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

ABSTRACT Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes viral preintegration complexes (PICs) to nuclear spe...

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Autores principales: Wen Li, Parmit K. Singh, Gregory A. Sowd, Gregory J. Bedwell, Sooin Jang, Vasudevan Achuthan, Amarachi V. Oleru, Doris Wong, Hind J. Fadel, KyeongEun Lee, Vineet N. KewalRamani, Eric M. Poeschla, Alon Herschhorn, Alan N. Engelman
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
CPSF6
integration
LEDGF/p75
human immunodeficiency virus
lentiviruses
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/7f4eaeb2c24147479988497d78e83da7
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https://doaj.org/article/7f4eaeb2c24147479988497d78e83da7

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