Dynamics of Neospora caninum-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme

Neospora caninum is an apicomplexan parasite that can cause abortions and perinatal mortality in sheep. Although ovine neosporosis has been described worldwide, there is a lack of information about the relationship between N. caninum serostatus and the reproduct...

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Autores principales:	Roberto Sánchez-Sánchez, Ángela Vázquez-Calvo, Mercedes Fernández-Escobar, Javier Regidor-Cerrillo, Julio Benavides, Jorge Gutiérrez, Daniel Gutiérrez-Expósito, Francisco José Crespo-Ramos, Luis Miguel Ortega-Mora, Gema Álvarez-García
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Neospora caninum</i> abortion sheep transmission route control programme Medicine R
Acceso en línea:	https://doaj.org/article/7f5172c4552644d38ca13e677bce794d
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spelling	oai:doaj.org-article:7f5172c4552644d38ca13e677bce794d2021-11-25T18:38:53ZDynamics of <i>Neospora caninum</i>-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme10.3390/pathogens101115182076-0817https://doaj.org/article/7f5172c4552644d38ca13e677bce794d2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1518https://doaj.org/toc/2076-0817<i>Neospora caninum</i> is an apicomplexan parasite that can cause abortions and perinatal mortality in sheep. Although ovine neosporosis has been described worldwide, there is a lack of information about the relationship between <i>N. caninum</i> serostatus and the reproductive performance. In this study, we described the infection dynamics in a dairy sheep flock with an abortion rate up to 25% and a <i>N. caninum</i> seroprevalence of 32%. Abortions were recorded in 36% and 9% of seropositive and seronegative sheep, respectively. Seropositive sheep were more likely to abort twice (OR = 4.44) or three or more times (OR = 10.13) than seronegative sheep. Endogenous transplacental transmission was the main route of transmission since 86% of seropositive sheep had seropositive offspring. Within dams that had any abortion, seropositive sheep were more likely than seronegative ones to have female descendants that aborted (OR = 8.12). The slight increase in seropositivity with the age, the low percentage of animals with postnatal seroconversion or with low avidity antibodies, and the seropositivity of one flock dog, indicated that horizontal transmission might have some relevance in this flock. A control programme based on selective culling of seropositive sheep and replacement with seronegative animals was effective in reducing the abortion rate to 7.2%.Roberto Sánchez-SánchezÁngela Vázquez-CalvoMercedes Fernández-EscobarJavier Regidor-CerrilloJulio BenavidesJorge GutiérrezDaniel Gutiérrez-ExpósitoFrancisco José Crespo-RamosLuis Miguel Ortega-MoraGema Álvarez-GarcíaMDPI AGarticle<i>Neospora caninum</i>abortionsheeptransmission routecontrol programmeMedicineRENPathogens, Vol 10, Iss 1518, p 1518 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Neospora caninum</i> abortion sheep transmission route control programme Medicine R
spellingShingle	<i>Neospora caninum</i> abortion sheep transmission route control programme Medicine R Roberto Sánchez-Sánchez Ángela Vázquez-Calvo Mercedes Fernández-Escobar Javier Regidor-Cerrillo Julio Benavides Jorge Gutiérrez Daniel Gutiérrez-Expósito Francisco José Crespo-Ramos Luis Miguel Ortega-Mora Gema Álvarez-García Dynamics of <i>Neospora caninum</i>-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme
description	<i>Neospora caninum</i> is an apicomplexan parasite that can cause abortions and perinatal mortality in sheep. Although ovine neosporosis has been described worldwide, there is a lack of information about the relationship between <i>N. caninum</i> serostatus and the reproductive performance. In this study, we described the infection dynamics in a dairy sheep flock with an abortion rate up to 25% and a <i>N. caninum</i> seroprevalence of 32%. Abortions were recorded in 36% and 9% of seropositive and seronegative sheep, respectively. Seropositive sheep were more likely to abort twice (OR = 4.44) or three or more times (OR = 10.13) than seronegative sheep. Endogenous transplacental transmission was the main route of transmission since 86% of seropositive sheep had seropositive offspring. Within dams that had any abortion, seropositive sheep were more likely than seronegative ones to have female descendants that aborted (OR = 8.12). The slight increase in seropositivity with the age, the low percentage of animals with postnatal seroconversion or with low avidity antibodies, and the seropositivity of one flock dog, indicated that horizontal transmission might have some relevance in this flock. A control programme based on selective culling of seropositive sheep and replacement with seronegative animals was effective in reducing the abortion rate to 7.2%.
format	article
author	Roberto Sánchez-Sánchez Ángela Vázquez-Calvo Mercedes Fernández-Escobar Javier Regidor-Cerrillo Julio Benavides Jorge Gutiérrez Daniel Gutiérrez-Expósito Francisco José Crespo-Ramos Luis Miguel Ortega-Mora Gema Álvarez-García
author_facet	Roberto Sánchez-Sánchez Ángela Vázquez-Calvo Mercedes Fernández-Escobar Javier Regidor-Cerrillo Julio Benavides Jorge Gutiérrez Daniel Gutiérrez-Expósito Francisco José Crespo-Ramos Luis Miguel Ortega-Mora Gema Álvarez-García
author_sort	Roberto Sánchez-Sánchez
title	Dynamics of <i>Neospora caninum</i>-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme
title_short	Dynamics of <i>Neospora caninum</i>-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme
title_full	Dynamics of <i>Neospora caninum</i>-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme
title_fullStr	Dynamics of <i>Neospora caninum</i>-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme
title_full_unstemmed	Dynamics of <i>Neospora caninum</i>-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme
title_sort	dynamics of <i>neospora caninum</i>-associated abortions in a dairy sheep flock and results of a test-and-cull control programme
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7f5172c4552644d38ca13e677bce794d
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Dynamics of <i>Neospora caninum</i>-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme

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