Metabolic landscape of the tumor microenvironment at single cell resolution

Each cell type in the tumour microenvironment has unique metabolic demands enabling specific functions. Here the authors use published single-cell RNA-seq data and develop a computational framework to better understand the heterogeneity of tumour metabolism, highlighting the discordance between resu...

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Detalles Bibliográficos
Autores principales: Zhengtao Xiao, Ziwei Dai, Jason W. Locasale
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7f52ab1626274a2580f7e81b6893c4ad
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Sumario:Each cell type in the tumour microenvironment has unique metabolic demands enabling specific functions. Here the authors use published single-cell RNA-seq data and develop a computational framework to better understand the heterogeneity of tumour metabolism, highlighting the discordance between results obtained from single cells and bulk tumours.