Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice

Yanjie Yang,1,2 Shuang-Yu Lv,2 Bianfei Yu,1 Shuang Xu,1 Jianmin Shen,3 Tong Zhao,1 Haixia Zhang1 1Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu, 2School of Medicine, Henan University, Kaifeng, Henan, 3Institute of Bioche...

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Autores principales:	Yang YJ, Lv SY, Yu BF, Xu S, Shen JM, Zhao T, Zhang HX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7f546d7583684c13bb54493e4cbadf91
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spelling	oai:doaj.org-article:7f546d7583684c13bb54493e4cbadf912021-12-02T00:46:37ZHepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice1178-2013https://doaj.org/article/7f546d7583684c13bb54493e4cbadf912015-09-01T00:00:00Zhttps://www.dovepress.com/hepatotoxicity-assessment-of-mn-doped-zns-quantum-dots-after-repeated--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yanjie Yang,1,2 Shuang-Yu Lv,2 Bianfei Yu,1 Shuang Xu,1 Jianmin Shen,3 Tong Zhao,1 Haixia Zhang1 1Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu, 2School of Medicine, Henan University, Kaifeng, Henan, 3Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China Abstract: Doped ZnS quantum dots (QDs) have a longer dopant emission lifetime and potentially lower cytotoxicity compared to other doped QDs. The liver is the key organ for clearance and detoxification of xenobiotics by phagocytosis and metabolism. The present study was designed to synthesize and evaluate the hepatotoxicity of Mn-doped ZnS QDs and their polyethylene glycol-coated counterparts (1 mg/kg and 5 mg/kg) in mice. The results demonstrated that daily injection of Mn-doped ZnS QDs and polyethylene glycol-coated QDs via tail vein for 7 days did not influence body weight, relative liver weight, serum aminotransferases (alanine aminotransferase and aspartate aminotransferase), the levels of antioxidant enzymes (catalase, glutathione peroxidase, and superoxide dismutase), or malondialdehyde in the liver. Analysis of hepatocyte ultrastructure showed that Mn-doped ZnS QDs and polyethylene glycol-coated QDs mainly accumulated in mitochondria at 24 hours after repeated intravenous injection. No damage to cell nuclei or mitochondria was observed with either of the QDs. Our results indicate that Mn-doped ZnS QDs did not cause obvious damage to the liver. This study will assist in the development of Mn-doped ZnS QDs-based bioimaging and biomedical applications in the future. Keywords: liver, serum aminotransferases, antioxidant enzymes, ultrastructureYang YJLv SYYu BFXu SShen JMZhao TZhang HXDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 5787-5796 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yang YJ Lv SY Yu BF Xu S Shen JM Zhao T Zhang HX Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice
description	Yanjie Yang,1,2 Shuang-Yu Lv,2 Bianfei Yu,1 Shuang Xu,1 Jianmin Shen,3 Tong Zhao,1 Haixia Zhang1 1Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou University, Lanzhou, Gansu, 2School of Medicine, Henan University, Kaifeng, Henan, 3Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China Abstract: Doped ZnS quantum dots (QDs) have a longer dopant emission lifetime and potentially lower cytotoxicity compared to other doped QDs. The liver is the key organ for clearance and detoxification of xenobiotics by phagocytosis and metabolism. The present study was designed to synthesize and evaluate the hepatotoxicity of Mn-doped ZnS QDs and their polyethylene glycol-coated counterparts (1 mg/kg and 5 mg/kg) in mice. The results demonstrated that daily injection of Mn-doped ZnS QDs and polyethylene glycol-coated QDs via tail vein for 7 days did not influence body weight, relative liver weight, serum aminotransferases (alanine aminotransferase and aspartate aminotransferase), the levels of antioxidant enzymes (catalase, glutathione peroxidase, and superoxide dismutase), or malondialdehyde in the liver. Analysis of hepatocyte ultrastructure showed that Mn-doped ZnS QDs and polyethylene glycol-coated QDs mainly accumulated in mitochondria at 24 hours after repeated intravenous injection. No damage to cell nuclei or mitochondria was observed with either of the QDs. Our results indicate that Mn-doped ZnS QDs did not cause obvious damage to the liver. This study will assist in the development of Mn-doped ZnS QDs-based bioimaging and biomedical applications in the future. Keywords: liver, serum aminotransferases, antioxidant enzymes, ultrastructure
format	article
author	Yang YJ Lv SY Yu BF Xu S Shen JM Zhao T Zhang HX
author_facet	Yang YJ Lv SY Yu BF Xu S Shen JM Zhao T Zhang HX
author_sort	Yang YJ
title	Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice
title_short	Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice
title_full	Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice
title_fullStr	Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice
title_full_unstemmed	Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice
title_sort	hepatotoxicity assessment of mn-doped zns quantum dots after repeated administration in mice
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/7f546d7583684c13bb54493e4cbadf91
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Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in&nbsp;mice

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