CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6

Analysing the 3D movement of MKLP1 motors, Maruyama et al. find that dimeric C. elegans MKLP1 drives a left-handed helical motion around the microtubule with minimum protofilament switching to the right side whereas less persistent motions are driven by monomers or by heterotetramers with CYK4. Thes...

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Autores principales: Yohei Maruyama, Mitsuhiro Sugawa, Shin Yamaguchi, Tim Davies, Toshihisa Osaki, Takuya Kobayashi, Masahiko Yamagishi, Shoji Takeuchi, Masanori Mishima, Junichiro Yajima
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7f54e877ab96495e8f23d8816609b535
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Sumario:Analysing the 3D movement of MKLP1 motors, Maruyama et al. find that dimeric C. elegans MKLP1 drives a left-handed helical motion around the microtubule with minimum protofilament switching to the right side whereas less persistent motions are driven by monomers or by heterotetramers with CYK4. These findings suggest how obstacles along crowded spindle microtubules may be avoided by CYK4 binding to MKLP1.