CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6

Analysing the 3D movement of MKLP1 motors, Maruyama et al. find that dimeric C. elegans MKLP1 drives a left-handed helical motion around the microtubule with minimum protofilament switching to the right side whereas less persistent motions are driven by monomers or by heterotetramers with CYK4. Thes...

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Autores principales:	Yohei Maruyama, Mitsuhiro Sugawa, Shin Yamaguchi, Tim Davies, Toshihisa Osaki, Takuya Kobayashi, Masahiko Yamagishi, Shoji Takeuchi, Masanori Mishima, Junichiro Yajima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7f54e877ab96495e8f23d8816609b535
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spelling	oai:doaj.org-article:7f54e877ab96495e8f23d8816609b5352021-12-02T14:11:03ZCYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-610.1038/s42003-021-01704-22399-3642https://doaj.org/article/7f54e877ab96495e8f23d8816609b5352021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01704-2https://doaj.org/toc/2399-3642Analysing the 3D movement of MKLP1 motors, Maruyama et al. find that dimeric C. elegans MKLP1 drives a left-handed helical motion around the microtubule with minimum protofilament switching to the right side whereas less persistent motions are driven by monomers or by heterotetramers with CYK4. These findings suggest how obstacles along crowded spindle microtubules may be avoided by CYK4 binding to MKLP1.Yohei MaruyamaMitsuhiro SugawaShin YamaguchiTim DaviesToshihisa OsakiTakuya KobayashiMasahiko YamagishiShoji TakeuchiMasanori MishimaJunichiro YajimaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yohei Maruyama Mitsuhiro Sugawa Shin Yamaguchi Tim Davies Toshihisa Osaki Takuya Kobayashi Masahiko Yamagishi Shoji Takeuchi Masanori Mishima Junichiro Yajima CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6
description	Analysing the 3D movement of MKLP1 motors, Maruyama et al. find that dimeric C. elegans MKLP1 drives a left-handed helical motion around the microtubule with minimum protofilament switching to the right side whereas less persistent motions are driven by monomers or by heterotetramers with CYK4. These findings suggest how obstacles along crowded spindle microtubules may be avoided by CYK4 binding to MKLP1.
format	article
author	Yohei Maruyama Mitsuhiro Sugawa Shin Yamaguchi Tim Davies Toshihisa Osaki Takuya Kobayashi Masahiko Yamagishi Shoji Takeuchi Masanori Mishima Junichiro Yajima
author_facet	Yohei Maruyama Mitsuhiro Sugawa Shin Yamaguchi Tim Davies Toshihisa Osaki Takuya Kobayashi Masahiko Yamagishi Shoji Takeuchi Masanori Mishima Junichiro Yajima
author_sort	Yohei Maruyama
title	CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6
title_short	CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6
title_full	CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6
title_fullStr	CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6
title_full_unstemmed	CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6
title_sort	cyk4 relaxes the bias in the off-axis motion by mklp1 kinesin-6
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7f54e877ab96495e8f23d8816609b535
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CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6

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