Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer

Abstract Breast cancer remains a common malignancy in women, but the take-up for breast cancer screening programs in Japan is still low, possibly due to its perceived inconvenience. TFF1 and TFF3 are expressed in both breast cancer tissue and normal breast. Serum trefoil proteins were reported as ca...

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Autores principales: Yuko Ishibashi, Hiroshi Ohtsu, Masako Ikemura, Yasuko Kikuchi, Takayoshi Niwa, Kotoe Nishioka, Yoshihiro Uchida, Hirona Miura, Susumu Aikou, Toshiaki Gunji, Nobuyuki Matsuhashi, Yasukazu Ohmoto, Takeshi Sasaki, Yasuyuki Seto, Toshihisa Ogawa, Keiichiro Tada, Sachiyo Nomura
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/7f5616ea3e334be1b84c86db8b61e9d9
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spelling oai:doaj.org-article:7f5616ea3e334be1b84c86db8b61e9d92021-12-02T12:30:37ZSerum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer10.1038/s41598-017-05129-y2045-2322https://doaj.org/article/7f5616ea3e334be1b84c86db8b61e9d92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05129-yhttps://doaj.org/toc/2045-2322Abstract Breast cancer remains a common malignancy in women, but the take-up for breast cancer screening programs in Japan is still low, possibly due to its perceived inconvenience. TFF1 and TFF3 are expressed in both breast cancer tissue and normal breast. Serum trefoil proteins were reported as cancer screening markers for gastric, prostate, lung, pancreatic cancer and cholangio carcinoma. The purpose of this study was to examine whether serum trefoil proteins could be screening biomarkers for breast cancer. Serum trefoil proteins in 94 breast cancer patients and 84 health check females were measured by ELISA. Serum TFF1 and TFF3 were significantly higher and serum TFF2 was significantly lower in breast cancer patients. Area under the curve of receiver operating characteristic of TFF1, TFF2, and TFF3 was 0.69, 0.83, and. 0.72, respectively. AUC of the combination of TFF1, TFF2, and TFF3 was 0.96. Immunohistochemically, TFF1 expression was positive in 56.5% and TFF3 was positive in 73.9% of breast cancers, while TFF2 was negative in all tumors. Serum TFF1 had positive correlation with expression of TFF1 in breast cancer tissue. Serum concentrations of TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.Yuko IshibashiHiroshi OhtsuMasako IkemuraYasuko KikuchiTakayoshi NiwaKotoe NishiokaYoshihiro UchidaHirona MiuraSusumu AikouToshiaki GunjiNobuyuki MatsuhashiYasukazu OhmotoTakeshi SasakiYasuyuki SetoToshihisa OgawaKeiichiro TadaSachiyo NomuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yuko Ishibashi
Hiroshi Ohtsu
Masako Ikemura
Yasuko Kikuchi
Takayoshi Niwa
Kotoe Nishioka
Yoshihiro Uchida
Hirona Miura
Susumu Aikou
Toshiaki Gunji
Nobuyuki Matsuhashi
Yasukazu Ohmoto
Takeshi Sasaki
Yasuyuki Seto
Toshihisa Ogawa
Keiichiro Tada
Sachiyo Nomura
Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer
description Abstract Breast cancer remains a common malignancy in women, but the take-up for breast cancer screening programs in Japan is still low, possibly due to its perceived inconvenience. TFF1 and TFF3 are expressed in both breast cancer tissue and normal breast. Serum trefoil proteins were reported as cancer screening markers for gastric, prostate, lung, pancreatic cancer and cholangio carcinoma. The purpose of this study was to examine whether serum trefoil proteins could be screening biomarkers for breast cancer. Serum trefoil proteins in 94 breast cancer patients and 84 health check females were measured by ELISA. Serum TFF1 and TFF3 were significantly higher and serum TFF2 was significantly lower in breast cancer patients. Area under the curve of receiver operating characteristic of TFF1, TFF2, and TFF3 was 0.69, 0.83, and. 0.72, respectively. AUC of the combination of TFF1, TFF2, and TFF3 was 0.96. Immunohistochemically, TFF1 expression was positive in 56.5% and TFF3 was positive in 73.9% of breast cancers, while TFF2 was negative in all tumors. Serum TFF1 had positive correlation with expression of TFF1 in breast cancer tissue. Serum concentrations of TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.
format article
author Yuko Ishibashi
Hiroshi Ohtsu
Masako Ikemura
Yasuko Kikuchi
Takayoshi Niwa
Kotoe Nishioka
Yoshihiro Uchida
Hirona Miura
Susumu Aikou
Toshiaki Gunji
Nobuyuki Matsuhashi
Yasukazu Ohmoto
Takeshi Sasaki
Yasuyuki Seto
Toshihisa Ogawa
Keiichiro Tada
Sachiyo Nomura
author_facet Yuko Ishibashi
Hiroshi Ohtsu
Masako Ikemura
Yasuko Kikuchi
Takayoshi Niwa
Kotoe Nishioka
Yoshihiro Uchida
Hirona Miura
Susumu Aikou
Toshiaki Gunji
Nobuyuki Matsuhashi
Yasukazu Ohmoto
Takeshi Sasaki
Yasuyuki Seto
Toshihisa Ogawa
Keiichiro Tada
Sachiyo Nomura
author_sort Yuko Ishibashi
title Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer
title_short Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer
title_full Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer
title_fullStr Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer
title_full_unstemmed Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer
title_sort serum tff1 and tff3 but not tff2 are higher in women with breast cancer than in women without breast cancer
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/7f5616ea3e334be1b84c86db8b61e9d9
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