Peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes
Cyrus v Desouza1,2, Lindsey Rentschler1, Vivian Fonseca31University of Nebraska Medical Center, 2Omaha VA Medical Center, Omaha, NE, USA; Scott & White Medical Clinic/Texas A & M College of Medicine, Temple, TX, USAAbstract: The incidence of diabetes is directly related to th...
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Dove Medical Press
2009
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oai:doaj.org-article:7f564b9762f84a58b44f7cf438b7a83f2021-12-02T06:55:55ZPeroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes1178-7007https://doaj.org/article/7f564b9762f84a58b44f7cf438b7a83f2009-09-01T00:00:00Zhttp://www.dovepress.com/peroxisome-proliferator-activated-receptors-as-stimulants-of-angiogene-a3577https://doaj.org/toc/1178-7007Cyrus v Desouza1,2, Lindsey Rentschler1, Vivian Fonseca31University of Nebraska Medical Center, 2Omaha VA Medical Center, Omaha, NE, USA; Scott & White Medical Clinic/Texas A & M College of Medicine, Temple, TX, USAAbstract: The incidence of diabetes is directly related to the incidence of obesity, which is at epidemic proportions in the US. Cardiovascular disease is a common complication of diabetes, which results in high morbidity and mortality. Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear hormone receptors that regulate lipid and glucose metabolism. PPAR-α agonists such as fenofibrate and PPAR-γ agonists such as the thiozolidinediones have been used to treat dyslipidemia and insulin resistance in diabetes. Over the past few years research has discovered the role of PPARs in the regulation of inflammation, proliferation, and angiogenesis. Clinical trials looking at the effect of PPAR agonists on cardiovascular outcomes have produced controversial results. Studies looking at angiogenesis and proliferation in various animal models and cell lines have shown a wide variation in results. This may be due to the differential effects of PPARs on proliferation and angiogenesis in various tissues and pathologic states. This review discusses the role of PPARs in stimulating angiogenesis. It also reviews the settings in which stimulation of angiogenesis may be either beneficial or harmful.Keywords: PPAR, VEGF, angiogenesis, cardiovascular Cyrus V DesouzaLindsey RentschlerVivian FonsecaDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2009, Iss default, Pp 165-172 (2009) |
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Specialties of internal medicine RC581-951 |
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Specialties of internal medicine RC581-951 Cyrus V Desouza Lindsey Rentschler Vivian Fonseca Peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes |
| description |
Cyrus v Desouza1,2, Lindsey Rentschler1, Vivian Fonseca31University of Nebraska Medical Center, 2Omaha VA Medical Center, Omaha, NE, USA; Scott & White Medical Clinic/Texas A & M College of Medicine, Temple, TX, USAAbstract: The incidence of diabetes is directly related to the incidence of obesity, which is at epidemic proportions in the US. Cardiovascular disease is a common complication of diabetes, which results in high morbidity and mortality. Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear hormone receptors that regulate lipid and glucose metabolism. PPAR-α agonists such as fenofibrate and PPAR-γ agonists such as the thiozolidinediones have been used to treat dyslipidemia and insulin resistance in diabetes. Over the past few years research has discovered the role of PPARs in the regulation of inflammation, proliferation, and angiogenesis. Clinical trials looking at the effect of PPAR agonists on cardiovascular outcomes have produced controversial results. Studies looking at angiogenesis and proliferation in various animal models and cell lines have shown a wide variation in results. This may be due to the differential effects of PPARs on proliferation and angiogenesis in various tissues and pathologic states. This review discusses the role of PPARs in stimulating angiogenesis. It also reviews the settings in which stimulation of angiogenesis may be either beneficial or harmful.Keywords: PPAR, VEGF, angiogenesis, cardiovascular |
| format |
article |
| author |
Cyrus V Desouza Lindsey Rentschler Vivian Fonseca |
| author_facet |
Cyrus V Desouza Lindsey Rentschler Vivian Fonseca |
| author_sort |
Cyrus V Desouza |
| title |
Peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes |
| title_short |
Peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes |
| title_full |
Peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes |
| title_fullStr |
Peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes |
| title_full_unstemmed |
Peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes |
| title_sort |
peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/7f564b9762f84a58b44f7cf438b7a83f |
| work_keys_str_mv |
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| _version_ |
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