Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson’s disease in patients with freezing of gait

Abstract Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled crossover trial we explored the role of nVNS in the treatment of gait and other motor sy...

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Autores principales:	Banashree Mondal, Supriyo Choudhury, Rebecca Banerjee, Akash Roy, Koustav Chatterjee, Purba Basu, Ravi Singh, Saptak Halder, Shantanu Shubham, Stuart N. Baker, Mark R. Baker, Hrishikesh Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7f570a20b1cf48adb3d0d022cab7459f
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spelling	oai:doaj.org-article:7f570a20b1cf48adb3d0d022cab7459f2021-12-02T14:49:19ZNon-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson’s disease in patients with freezing of gait10.1038/s41531-021-00190-x2373-8057https://doaj.org/article/7f570a20b1cf48adb3d0d022cab7459f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00190-xhttps://doaj.org/toc/2373-8057Abstract Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled crossover trial we explored the role of nVNS in the treatment of gait and other motor symptoms in Parkinson’s disease (PD) patients. In a subgroup of patients, we measured selected neurotrophin levels and markers of inflammation and oxidative stress in serum, before and after the experimental intervention. Thirty-three PD patients with associated freezing of gait were randomised to either nVNS or sham. After baseline assessments, patients were instructed to deliver 6 two-minute stimulations (total 12 min/day) of the nVNS/sham device (electroCore, Inc. USA) for one month at home. Patients were then re-assessed. After a washout period of one month, the same patients were allocated to the alternate treatment arm and the same process was followed. Significant improvements in key gait parameters were observed with nVNS, including walking speed, stance time and step length, compared to sham. Similarly, overall motor function (MDS-UPDRS III) also improved significantly following nVNS stimulation. Serum Tumor Necrosis Factor (TNF)-α and glutathione levels decreased and brain-derived neurotrophic factor (BDNF) levels increased significantly (p < 0.05) after treatment with nVNS. Here we present the first double-blind sham-controlled trial evidence of the efficacy and safety of nVNS in the treatment of gait and motor function in patients with PD.Banashree MondalSupriyo ChoudhuryRebecca BanerjeeAkash RoyKoustav ChatterjeePurba BasuRavi SinghSaptak HalderShantanu ShubhamStuart N. BakerMark R. BakerHrishikesh KumarNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Banashree Mondal Supriyo Choudhury Rebecca Banerjee Akash Roy Koustav Chatterjee Purba Basu Ravi Singh Saptak Halder Shantanu Shubham Stuart N. Baker Mark R. Baker Hrishikesh Kumar Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson’s disease in patients with freezing of gait
description	Abstract Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled crossover trial we explored the role of nVNS in the treatment of gait and other motor symptoms in Parkinson’s disease (PD) patients. In a subgroup of patients, we measured selected neurotrophin levels and markers of inflammation and oxidative stress in serum, before and after the experimental intervention. Thirty-three PD patients with associated freezing of gait were randomised to either nVNS or sham. After baseline assessments, patients were instructed to deliver 6 two-minute stimulations (total 12 min/day) of the nVNS/sham device (electroCore, Inc. USA) for one month at home. Patients were then re-assessed. After a washout period of one month, the same patients were allocated to the alternate treatment arm and the same process was followed. Significant improvements in key gait parameters were observed with nVNS, including walking speed, stance time and step length, compared to sham. Similarly, overall motor function (MDS-UPDRS III) also improved significantly following nVNS stimulation. Serum Tumor Necrosis Factor (TNF)-α and glutathione levels decreased and brain-derived neurotrophic factor (BDNF) levels increased significantly (p < 0.05) after treatment with nVNS. Here we present the first double-blind sham-controlled trial evidence of the efficacy and safety of nVNS in the treatment of gait and motor function in patients with PD.
format	article
author	Banashree Mondal Supriyo Choudhury Rebecca Banerjee Akash Roy Koustav Chatterjee Purba Basu Ravi Singh Saptak Halder Shantanu Shubham Stuart N. Baker Mark R. Baker Hrishikesh Kumar
author_facet	Banashree Mondal Supriyo Choudhury Rebecca Banerjee Akash Roy Koustav Chatterjee Purba Basu Ravi Singh Saptak Halder Shantanu Shubham Stuart N. Baker Mark R. Baker Hrishikesh Kumar
author_sort	Banashree Mondal
title	Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson’s disease in patients with freezing of gait
title_short	Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson’s disease in patients with freezing of gait
title_full	Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson’s disease in patients with freezing of gait
title_fullStr	Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson’s disease in patients with freezing of gait
title_full_unstemmed	Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson’s disease in patients with freezing of gait
title_sort	non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of parkinson’s disease in patients with freezing of gait
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7f570a20b1cf48adb3d0d022cab7459f
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Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson’s disease in patients with freezing of gait

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