Regulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk

Cardiovascular disease is strongly influenced by platelet activation. Platelet activation and thrombus formation at atherosclerotic plaque rupture sites is a dynamic process regulated by different signaling networks. Therefore, there are now focused efforts to search for novel bioactive compounds wh...

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Autores principales:	Eduardo Fuentes, Sergio Wehinger, Andrés Trostchansky
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bioactive compounds hemostasis platelet thrombosis bleeding Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7f5834e78bdc4c7e9cc16918eb7d8016
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spelling	oai:doaj.org-article:7f5834e78bdc4c7e9cc16918eb7d80162021-11-25T17:55:58ZRegulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk10.3390/ijms2222123801422-00671661-6596https://doaj.org/article/7f5834e78bdc4c7e9cc16918eb7d80162021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12380https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cardiovascular disease is strongly influenced by platelet activation. Platelet activation and thrombus formation at atherosclerotic plaque rupture sites is a dynamic process regulated by different signaling networks. Therefore, there are now focused efforts to search for novel bioactive compounds which target receptors and pathways in the platelet activation process while preserving normal hemostatic function. The antiplatelet activity of numerous fruits and vegetables and their multiple mechanisms of action have recently been highlighted. In this review, we review the antiplatelet actions of bioactive compounds via key pathways (protein disulfide isomerase, mitogen-activated protein kinases, mitochondrial function, cyclic adenosine monophosphate, Akt, and shear stress-induced platelet aggregation) with no effects on bleeding time. Therefore, targeting these pathways might lead to the development of effective antiplatelet strategies that do not increase the risk of bleeding.Eduardo FuentesSergio WehingerAndrés TrostchanskyMDPI AGarticlebioactive compoundshemostasisplateletthrombosisbleedingBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12380, p 12380 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioactive compounds hemostasis platelet thrombosis bleeding Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	bioactive compounds hemostasis platelet thrombosis bleeding Biology (General) QH301-705.5 Chemistry QD1-999 Eduardo Fuentes Sergio Wehinger Andrés Trostchansky Regulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk
description	Cardiovascular disease is strongly influenced by platelet activation. Platelet activation and thrombus formation at atherosclerotic plaque rupture sites is a dynamic process regulated by different signaling networks. Therefore, there are now focused efforts to search for novel bioactive compounds which target receptors and pathways in the platelet activation process while preserving normal hemostatic function. The antiplatelet activity of numerous fruits and vegetables and their multiple mechanisms of action have recently been highlighted. In this review, we review the antiplatelet actions of bioactive compounds via key pathways (protein disulfide isomerase, mitogen-activated protein kinases, mitochondrial function, cyclic adenosine monophosphate, Akt, and shear stress-induced platelet aggregation) with no effects on bleeding time. Therefore, targeting these pathways might lead to the development of effective antiplatelet strategies that do not increase the risk of bleeding.
format	article
author	Eduardo Fuentes Sergio Wehinger Andrés Trostchansky
author_facet	Eduardo Fuentes Sergio Wehinger Andrés Trostchansky
author_sort	Eduardo Fuentes
title	Regulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk
title_short	Regulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk
title_full	Regulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk
title_fullStr	Regulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk
title_full_unstemmed	Regulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk
title_sort	regulation of key antiplatelet pathways by bioactive compounds with minimal bleeding risk
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7f5834e78bdc4c7e9cc16918eb7d8016
work_keys_str_mv	AT eduardofuentes regulationofkeyantiplateletpathwaysbybioactivecompoundswithminimalbleedingrisk AT sergiowehinger regulationofkeyantiplateletpathwaysbybioactivecompoundswithminimalbleedingrisk AT andrestrostchansky regulationofkeyantiplateletpathwaysbybioactivecompoundswithminimalbleedingrisk
_version_	1718411812189241344

Regulation of Key Antiplatelet Pathways by Bioactive Compounds with Minimal Bleeding Risk

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