Ethanol resistance in Drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations

Abstract Understanding the genetic properties of adaptive trait evolution is a fundamental crux of biological inquiry that links molecular processes to biological diversity. Important uncertainties persist regarding the genetic predictability of adaptive trait change, the role of standing variation,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Quentin D. Sprengelmeyer, John E. Pool
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	adaptive evolution alcohol Drosophila melanogaster genetic architecture genetic differentiation local adaptation Ecology QH540-549.5
Acceso en línea:	https://doaj.org/article/7f5988a9ffe44b64bb3f5c32f5009a35
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7f5988a9ffe44b64bb3f5c32f5009a35
record_format	dspace
spelling	oai:doaj.org-article:7f5988a9ffe44b64bb3f5c32f5009a352021-11-08T17:10:41ZEthanol resistance in Drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations2045-775810.1002/ece3.8228https://doaj.org/article/7f5988a9ffe44b64bb3f5c32f5009a352021-11-01T00:00:00Zhttps://doi.org/10.1002/ece3.8228https://doaj.org/toc/2045-7758Abstract Understanding the genetic properties of adaptive trait evolution is a fundamental crux of biological inquiry that links molecular processes to biological diversity. Important uncertainties persist regarding the genetic predictability of adaptive trait change, the role of standing variation, and whether adaptation tends to result in the fixation of favored variants. Here, we use the recurrent evolution of enhanced ethanol resistance in Drosophila melanogaster during this species’ worldwide expansion as a promising system to add to our understanding of the genetics of adaptation. We find that elevated ethanol resistance has evolved at least three times in different cooler regions of the species’ modern range—not only at high latitude but also in two African high‐altitude regions. Applying a bulk segregant mapping framework, we find that the genetic architecture of ethanol resistance evolution differs substantially not only between our three resistant populations, but also between two crosses involving the same European population. We then apply population genetic scans for local adaptation within our quantitative trait locus regions, and we find potential contributions of genes with annotated roles in spindle localization, membrane composition, sterol and alcohol metabolism, and other processes. We also apply simulation‐based analyses that confirm the variable genetic basis of ethanol resistance and hint at a moderately polygenic architecture. However, these simulations indicate that larger‐scale studies will be needed to more clearly quantify the genetic architecture of adaptive evolution and to firmly connect trait evolution to specific causative loci.Quentin D. SprengelmeyerJohn E. PoolWileyarticleadaptive evolutionalcoholDrosophila melanogastergenetic architecturegenetic differentiationlocal adaptationEcologyQH540-549.5ENEcology and Evolution, Vol 11, Iss 21, Pp 15364-15376 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adaptive evolution alcohol Drosophila melanogaster genetic architecture genetic differentiation local adaptation Ecology QH540-549.5
spellingShingle	adaptive evolution alcohol Drosophila melanogaster genetic architecture genetic differentiation local adaptation Ecology QH540-549.5 Quentin D. Sprengelmeyer John E. Pool Ethanol resistance in Drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations
description	Abstract Understanding the genetic properties of adaptive trait evolution is a fundamental crux of biological inquiry that links molecular processes to biological diversity. Important uncertainties persist regarding the genetic predictability of adaptive trait change, the role of standing variation, and whether adaptation tends to result in the fixation of favored variants. Here, we use the recurrent evolution of enhanced ethanol resistance in Drosophila melanogaster during this species’ worldwide expansion as a promising system to add to our understanding of the genetics of adaptation. We find that elevated ethanol resistance has evolved at least three times in different cooler regions of the species’ modern range—not only at high latitude but also in two African high‐altitude regions. Applying a bulk segregant mapping framework, we find that the genetic architecture of ethanol resistance evolution differs substantially not only between our three resistant populations, but also between two crosses involving the same European population. We then apply population genetic scans for local adaptation within our quantitative trait locus regions, and we find potential contributions of genes with annotated roles in spindle localization, membrane composition, sterol and alcohol metabolism, and other processes. We also apply simulation‐based analyses that confirm the variable genetic basis of ethanol resistance and hint at a moderately polygenic architecture. However, these simulations indicate that larger‐scale studies will be needed to more clearly quantify the genetic architecture of adaptive evolution and to firmly connect trait evolution to specific causative loci.
format	article
author	Quentin D. Sprengelmeyer John E. Pool
author_facet	Quentin D. Sprengelmeyer John E. Pool
author_sort	Quentin D. Sprengelmeyer
title	Ethanol resistance in Drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations
title_short	Ethanol resistance in Drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations
title_full	Ethanol resistance in Drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations
title_fullStr	Ethanol resistance in Drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations
title_full_unstemmed	Ethanol resistance in Drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations
title_sort	ethanol resistance in drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/7f5988a9ffe44b64bb3f5c32f5009a35
work_keys_str_mv	AT quentindsprengelmeyer ethanolresistanceindrosophilamelanogasterhasincreasedinparallelcoldadaptedpopulationsandshowsavariablegeneticarchitecturewithinandbetweenpopulations AT johnepool ethanolresistanceindrosophilamelanogasterhasincreasedinparallelcoldadaptedpopulationsandshowsavariablegeneticarchitecturewithinandbetweenpopulations
_version_	1718441489523015680

Ethanol resistance in Drosophila melanogaster has increased in parallel cold‐adapted populations and shows a variable genetic architecture within and between populations

Ejemplares similares