Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?

Bruno Bordoni,1 Fabiola Marelli,2,3 Bruno Morabito,2–4 Francesca Cavallaro,5 David Lintonbon6 1Foundation Don Carlo Gnocchi IRCCS, Department of Cardiology, Institute of Hospitalization and Care with Scientific, Milan, Italy; 2CRESO, School of Osteopathic Center for Research and Studies, D...

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Autores principales:	Bordoni B, Marelli F, Morabito B, Cavallaro F, Lintonbon D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Fibromyalgia Fascia Pain Myofascial Neuropathic pain. Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/7f606773ac1c44f28cc23fb1c8bb4edc
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spelling	oai:doaj.org-article:7f606773ac1c44f28cc23fb1c8bb4edc2021-12-02T05:55:41ZFascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?1179-156Xhttps://doaj.org/article/7f606773ac1c44f28cc23fb1c8bb4edc2018-05-01T00:00:00Zhttps://www.dovepress.com/fascial-preadipocytes-another-missing-piece-of-the-puzzle-to-understan-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XBruno Bordoni,1 Fabiola Marelli,2,3 Bruno Morabito,2–4 Francesca Cavallaro,5 David Lintonbon6 1Foundation Don Carlo Gnocchi IRCCS, Department of Cardiology, Institute of Hospitalization and Care with Scientific, Milan, Italy; 2CRESO, School of Osteopathic Center for Research and Studies, Department of Fascial Osteopathic Research: FORe, Gorla Minore, Italy; 3CRESO, School of Osteopathic Center for Research and Studies, Department of Fascial Osteopathic Research, Fano, Italy; 4Sapienza University of Rome, Department of Radiological, Oncological and Anatomopathological Sciences, Rome, Italy; 5ICOM, International College of Osteopathic Medicine, Torino, Italy; 6London School of Osteopathy, Department of Osteopathic Technique, London, UK Abstract: Fibromyalgia (FM) syndrome is a chronic condition causing pain, affecting approximately 0.5%–6% of the developed countries’ population, and on average, 2% of the worldwide population. Despite the large amount of scientific literature available, the FM etiology is still uncertain. The diagnosis is based on the clinical presentation and the severity of the symptomatology. Several studies pointed out pathological alterations within the central nervous system, suggesting that FM could originate from a central sensitization of the pain processing centers. Research supports the thesis of a peripheral neuropathic component, with the finding of axonal damages. The fibromyalgia patient has many myofascial system abnormalities, such as pain and fatigue, impairing the symptomatic profile. This paper revises the myopathic compensations, highlighting the possible role of the fascia in generating symptoms, being aware of the new information about the fascia’s activity in stimulating inflammation and fat cell production. Keywords: fibromyalgia, fascia, pain, myofascial, neuropathic painBordoni BMarelli FMorabito BCavallaro FLintonbon DDove Medical PressarticleFibromyalgiaFasciaPainMyofascialNeuropathic pain.Diseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 10, Pp 27-32 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fibromyalgia Fascia Pain Myofascial Neuropathic pain. Diseases of the musculoskeletal system RC925-935
spellingShingle	Fibromyalgia Fascia Pain Myofascial Neuropathic pain. Diseases of the musculoskeletal system RC925-935 Bordoni B Marelli F Morabito B Cavallaro F Lintonbon D Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?
description	Bruno Bordoni,1 Fabiola Marelli,2,3 Bruno Morabito,2–4 Francesca Cavallaro,5 David Lintonbon6 1Foundation Don Carlo Gnocchi IRCCS, Department of Cardiology, Institute of Hospitalization and Care with Scientific, Milan, Italy; 2CRESO, School of Osteopathic Center for Research and Studies, Department of Fascial Osteopathic Research: FORe, Gorla Minore, Italy; 3CRESO, School of Osteopathic Center for Research and Studies, Department of Fascial Osteopathic Research, Fano, Italy; 4Sapienza University of Rome, Department of Radiological, Oncological and Anatomopathological Sciences, Rome, Italy; 5ICOM, International College of Osteopathic Medicine, Torino, Italy; 6London School of Osteopathy, Department of Osteopathic Technique, London, UK Abstract: Fibromyalgia (FM) syndrome is a chronic condition causing pain, affecting approximately 0.5%–6% of the developed countries’ population, and on average, 2% of the worldwide population. Despite the large amount of scientific literature available, the FM etiology is still uncertain. The diagnosis is based on the clinical presentation and the severity of the symptomatology. Several studies pointed out pathological alterations within the central nervous system, suggesting that FM could originate from a central sensitization of the pain processing centers. Research supports the thesis of a peripheral neuropathic component, with the finding of axonal damages. The fibromyalgia patient has many myofascial system abnormalities, such as pain and fatigue, impairing the symptomatic profile. This paper revises the myopathic compensations, highlighting the possible role of the fascia in generating symptoms, being aware of the new information about the fascia’s activity in stimulating inflammation and fat cell production. Keywords: fibromyalgia, fascia, pain, myofascial, neuropathic pain
format	article
author	Bordoni B Marelli F Morabito B Cavallaro F Lintonbon D
author_facet	Bordoni B Marelli F Morabito B Cavallaro F Lintonbon D
author_sort	Bordoni B
title	Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?
title_short	Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?
title_full	Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?
title_fullStr	Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?
title_full_unstemmed	Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?
title_sort	fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/7f606773ac1c44f28cc23fb1c8bb4edc
work_keys_str_mv	AT bordonib fascialpreadipocytesanothermissingpieceofthepuzzletounderstandfibromyalgia AT marellif fascialpreadipocytesanothermissingpieceofthepuzzletounderstandfibromyalgia AT morabitob fascialpreadipocytesanothermissingpieceofthepuzzletounderstandfibromyalgia AT cavallarof fascialpreadipocytesanothermissingpieceofthepuzzletounderstandfibromyalgia AT lintonbond fascialpreadipocytesanothermissingpieceofthepuzzletounderstandfibromyalgia
_version_	1718400180326236160

Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?

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